MRI properties of a unique hypo-intense layer in degraded articular cartilage.
MRI properties of a unique hypo-intense layer in degraded articular cartilage.
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DOI：
10.1088/0031-9155/60/22/8709
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发表时间：
2015-11-21
影响因子：
3.5
通讯作者：
Xia Y
中科院分区：
文献类型：
--
作者：
Wang N;Badar F;Xia Y
为了研究关节软骨在外部载荷下低强度层状外观的特征，在不同的浸泡溶液（生理盐水和100 mM PBS）中对总共15个健康和胰蛋白酶降解软骨标本进行显微镜MRI（μMRI）T1、T2和T1ρ实验。生理盐水中健康组织的T2和T1ρ图像未显示负载诱导的层状外观，而在魔角处降解组织的深部清晰可见低强度层。在0°和55°（从16.5 ± 2.8 ms到20.2 ± 2.7 ms，p=0.0005）以及0°和90°（16.5 ± 2.8 ms到21.3 ± 2.6 ms，p<0.0001）时，生理盐水溶液中的T2值之间存在显著差异。相比之下，当组织浸泡在PBS中时，这种低强度片状外观基本消失。这种低强度的外观在不同的浸泡介质中的可视化要求谨慎解释弛豫时间，化学交换和胶原纤维变形的数据。
To investigate the characteristics of a hypo-intense laminar appearance in articular cartilage under external loading, microscopic MRI (μMRI) T1, T2 and T1ρ experiments of total 15 specimens of healthy and trypsin-degraded cartilage were performed at different soaking solutions (saline and 100 mM PBS). T2 and T1ρ images of the healthy tissue in saline showed no load-induced laminar appearance, while a hypo-intense layer was clearly visible in the deep part of the degraded tissue at the magic angle. Significant difference was found between T2 values at 0° and 55° (from 16.5 ± 2.8 ms to 20.2 ± 2.7 ms, p=0.0005), and at 0° and 90° (16.5 ± 2.8 ms to 21.3 ± 2.6 ms, p<0.0001) in saline solution. In contrast, this hypo-intense laminar appearance largely disappeared when tissue was soaked in PBS. The visualization of this hypo-intensity appearance in different soaking mediums calls for caution in interpreting the data of relaxation times, chemical exchange, and collagen fiber deformation.