Body composition analysis within 1 month after gastrectomy for gastric cancer
Body composition analysis within 1 month after gastrectomy for gastric cancer
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DOI：
10.1007/s10120-015-0496-x
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发表时间：
2016-04-01
期刊：
影响因子：
7.4
通讯作者：
Yoshikawa, Takaki
中科院分区：
文献类型：
--
作者：
Aoyama, Toru;Kawabe, Taiichi;Yoshikawa, Takaki
胃癌患者在胃切除术后1个月内体重明显下降。然而，目前还不清楚是哪一种身体成分导致了体重的下降。2010年5月至2013年10月期间，244名因胃癌接受胃切除术的患者接受了检查。术前1周（第一次测量）、术后1周（第二次测量）、术后1个月（第三次测量）用生物电阻抗分析仪评估体重和身体成分。前期的变化定义为第二次测量之前的差异，后期的变化定义为第二次到第三次测量之间的差异。1个月内总体重为-3.4 kg， 1个月体重恢复至术前体重的比率为94.1%。体重在前期显著大于后期（-2.1 kg vs -1.2 kg, p < 0.001）。在早期，瘦体重的减少明显大于脂肪体重的减少（-1.5 kg vs -0.6 kg, p < 0.001）。当排除有手术并发症的患者亚群时，观察到同样的趋势。术后1周BWL明显大于术后3周BWL。此外，瘦体质量的损失在第一周内占BWL的重要部分。
A significant body weight loss (BWL) is observed during 1 month after gastrectomy for gastric cancer. However, it remains unclear which body component mainly accounts for the weight loss.Two-hundred forty-four patients who underwent gastrectomy for gastric cancer between May 2010 and October 2013 were examined. Body weight and composition were evaluated by a bioelectrical impedance analyzer within 1 week before surgery (first measurement), at 1 week after surgery (second measurement), and at 1 month after surgery (third measurement). The changes in the early period were defined as the differences until the second measurement, and those in the late period were defined as the differences from the second to the third measurement.Total BWL within 1 month was -3.4 kg, and the rate of body weight at 1 month to the preoperative body weight was 94.1 %. BWL was significantly greater in the early period than in the late period (-2.1 kg vs -1.2 kg, p < 0.001). In the early period, loss of lean body mass was significantly greater than loss of fat mass (-1.5 kg vs -0.6 kg, p < 0.001). The same trend was observed when the subset of patients who had surgical morbidities was excluded.BWL during the first week after surgery was significantly greater than that during the subsequent 3 weeks. Furthermore, loss of lean body mass accounted for a significant part of the BWL during the first week.