The effects of food on methotrexate absorption.
The effects of food on methotrexate absorption.
复制标题
食物对甲氨蝶呤吸收的影响。
作者：
R. Hamilton;J. Kremer
目的
确定食物对接受甲氨蝶呤（MTX）治疗的类风湿关节炎（RA）患者吸收MTX的影响。
方法
在RA患者服用常规维持剂量MTX后，在空腹状态下和吃标准早餐后测定标准药代动力学变量。
结果
2种给药条件之间在血清浓度-时间曲线下面积、给药后最大MTX浓度（Cmax）、至Cmax的时间、生物利用度、尿MTX、MTX的肾脏清除率或肌酸酐清除率方面没有观察到显着差异。
结论
我们没有观察到食物对MTX吸收或生物利用度的显著影响。患者可以在不考虑膳食的情况下服用MTX。
OBJECTIVE
To determine the effects of food on methotrexate (MTX) absorption in patients receiving MTX for the treatment of rheumatoid arthritis (RA).
METHODS
Standard pharmacokinetic variables were determined in patients with RA after their usual maintenance dose of MTX, under fasting conditions and after they ate a standard breakfast.
RESULTS
No significant differences in area under the serum concentration versus time curve, maximal MTX concentration after dosing (Cmax), time to Cmax), bioavailability, urinary MTX, renal clearance of MTX, or creatinine clearance were observed between the 2 dosing conditions.
CONCLUSION
We observed no significant effect of food on MTX absorption or bioavailability. Patients may consume MTX without regard to meals.