The Emerging Role of Ferroptosis in Cardiovascular Diseases.
The Emerging Role of Ferroptosis in Cardiovascular Diseases.
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铁性下垂在心血管疾病中的新作用。
DOI：
10.3389/fphar.2022.822083
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发表时间：
2022
影响因子：
5.6
通讯作者：
Xu Y
中科院分区：
文献类型：
--
作者：
Hong M;Rong J;Tao X;Xu Y
铁凋亡是近年来发现的一种以铁依赖性脂质过氧化为特征的细胞程序性死亡，参与铁、脂质和抗氧化剂的代谢。铁凋亡在形态学、生物化学和遗传学上与传统的细胞死亡类型如凋亡、坏死性凋亡和自噬不同。心血管疾病被认为是全球人口非传染性疾病死亡的重要原因，对人类健康构成严重威胁。细胞凋亡一直被认为是心肌细胞死亡的主要类型，但现在铁凋亡已被证明在心血管疾病中也起着重要作用。本文就铁凋亡的机制及其对心血管疾病发生发展的影响等相关问题进行综述，旨在为心血管疾病的防治提供新的靶点。
Ferroptosis is one type of programmed cell death discovered in recent years, which is characterized by iron-dependent lipid peroxidation and participating in iron, lipid and antioxidant metabolism. Ferroptosis is different from the traditional cell death types such as apoptosis, necroptosis and autophagy in morphology, biochemistry and genetics. Cardiovascular diseases are considered as an important cause of death from non-communicable diseases in the global population and poses a serious threat to human health. Apoptosis has long been thought to be the major type of cardiomyocyte death, but now ferroptosis has been shown to play a major role in cardiovascular diseases as well. This review will discuss related issues such as the mechanisms of ferroptosis and its effects on the occurrence and development of cardiovascular diseases, aiming to provide a novel target for the prevention and treatment of cardiovascular diseases.
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ACSL4 通过塑造细胞脂质成分来决定铁死亡敏感性。
影响因子：
14.8
作者：
Doll S;Proneth B;Tyurina YY;Panzilius E;Kobayashi S;Ingold I;Irmler M;Beckers J;Aichler M;Walch A;Prokisch H;Trümbach D;Mao G;Qu F;Bayir H;Füllekrug J;Scheel CH;Wurst W;Schick JA;Kagan VE;Angeli JP;Conrad M
通讯作者：
Conrad M
影响因子：
64.5
作者：
Dixon SJ;Lemberg KM;Lamprecht MR;Skouta R;Zaitsev EM;Gleason CE;Patel DN;Bauer AJ;Cantley AM;Yang WS;Morrison B 3rd;Stockwell BR
通讯作者：
Stockwell BR
影响因子：
4
作者：
Dixon SJ;Winter GE;Musavi LS;Lee ED;Snijder B;Rebsamen M;Superti-Furga G;Stockwell BR
通讯作者：
Stockwell BR
影响因子：
7.4
作者：
Berdoukas, Vasilios;Coates, Thomas D.;Cabantchik, Zvi Ioav
通讯作者：
Cabantchik, Zvi Ioav
DOI：
10.1016/j.bbamcr.2007.01.007
发表时间：
2007-04-01
影响因子：
5.1
作者：
Chua, Chu Chang;Gao, Jinping;Chua, Balvin H. L.
通讯作者：
Chua, Balvin H. L.