Potential metabolic activities of raspberry ketone.
Potential metabolic activities of raspberry ketone.
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DOI：
10.1111/jfbc.14018
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发表时间：
2021-12
影响因子：
4
通讯作者：
Xiao-ping Li;Teng Wei;Minchen Wu;Fang Chen;Peng Zhang;Z. Deng;Ting Luo
中科院分区：
文献类型：
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作者：
Xiao-ping Li;Teng Wei;Minchen Wu;Fang Chen;Peng Zhang;Z. Deng;Ting Luo
新的食品和食品化合物干预措施现在已经引起了人们对预防和治疗代谢性疾病的广泛关注。乌藨子酮（RK）是在红色水果和浆果中发现的芳香化合物，已被用作减肥的非处方产品。然而，实际上，RK减肥的效果仍然存在争议，其机制在很大程度上是未知的。此外，体内和体外研究已经证明RK对其他代谢性疾病的发展具有有益作用。本文综述了RK的合成、生物利用度、代谢等方面的研究进展，并对RK的抗肥胖、抗糖尿病、心脏保护和肝脏保护等潜在生物活性及其作用机制进行了综述。本文对当前的研究结果进行了批判性概述，并提出了RK对人类健康领域未来的研究方向。实际应用：乌藨子酮（RK）多年来一直用于控制体重，但考虑到食物摄入量，这种效果存在争议。此外，RK对T2DM、肝脏和心脏损伤有益。RK的保护作用机制包括促进脂肪酸氧化、平衡血糖、抗炎、抗氧化等，本文就RK对多种代谢性疾病的保护作用进行了综述，并对其分子机制进行了探讨。希望本文的工作能对RK的进一步研究和提高公众对RK的认知度有所帮助。
Novel food and food compounds interventions have attracted a lot of attention nowadays for the prevention and treatment of metabolic diseases. Raspberry ketone (RK) is aromatic compound found within red fruits and berries, has been used as an over-the-counter product for weight loss. However, actually, the effect of RK on weight loss is still controversial, and the mechanism is largely unknown. Besides, in vivo and in vitro studies have demonstrated the beneficial effect of RK on the development of other metabolic diseases. In this review, we comprehensively highlighted the synthesis, bioavailability, and metabolism of RK, and summarized the progress made in our understanding of the potential biological activities of RK, including antiobesity, antidiabetes, cardioprotection, and hepatoprotection, as well as their underlying mechanisms. This paper provides a critical overview about the current findings and proposes the future studies in the area of RK on human health. PRACTICAL APPLICATIONS: Raspberry ketone (RK) has been used for weight control for years, but this effect is controversial considering food intake. Additionally, RK is beneficial for T2DM, liver and heart injury. The underlying mechanisms of the protective effect of RK including accelerating fatty acid oxidation, balancing serum glucose level, anti-inflammation, antioxidant process, and so on. In this context, we provide a comprehensive analysis of the benefits of RK against many metabolic diseases and discuss the underlying molecular mechanisms. We hope our work will be helpful for further researches on RK and improve its public recognition.