INVITRO DUPLICATION AND CURE OF HEMATOPOIETIC DEFECTS IN GENETICALLY ANEMIC MICE
INVITRO DUPLICATION AND CURE OF HEMATOPOIETIC DEFECTS IN GENETICALLY ANEMIC MICE
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DOI：
10.1038/269412a0
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发表时间：
1977-01-01
期刊：
影响因子：
64.8
通讯作者：
MOORE, MAS
中科院分区：
文献类型：
--
作者：
DEXTER, TM;MOORE, MAS
在小鼠中描述了几种类型的先天性、遗传决定的大红细胞贫血1 -4。这些模型提供了一种手段，分析在造血组织支持干细胞增殖和分化的能力，并允许在干细胞的分化能力的内在缺陷的突变的影响。但是，分析这些突变及其对多能干细胞控制的影响受到缺乏技术的阻碍，特别是缺乏体外系统，以进一步确定干细胞和造血诱导微环境之间的相互作用。在此我们报道了在W和Steel（S1）小鼠中观察到的造血缺陷已在体外成功复制。
SEVERAL types of congenital, genetically determined macrocytic anaemias have been described in mice1–4. These models offer a means of analysing the effects of mutations at defined loci on the ability of haemopoietic tissue to support stem cell proliferation and differentiation and allow studies on intrinsic defects in differentiation capacity of stem cells. But, analysis of these mutations and their implications in relation to pluripotential stem cell control have been hampered by lack of techniques, particularly ofin vitrosystems, for further defining regulatory interactions between stem cells and the haemopoietic inductive microenvironment. Here we report that the haemopoietic defects seen in W and Steel (S1) mice have been successfully reproducedin vitro.