Analysis of Viscoelastic Wall Properties in Ovine Arteries
Analysis of Viscoelastic Wall Properties in Ovine Arteries
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DOI：
10.1109/tbme.2008.2003093
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发表时间：
2009-02-01
影响因子：
4.6
通讯作者：
Olufsen, Mette S.
中科院分区：
文献类型：
--
作者：
Valdez-Jasso, Daniela;Haider, Mansoor A.;Olufsen, Mette S.
在这篇文章中，我们分析了11只绵羊大动脉沿线七个位置的弹性和粘弹性特性的差异。我们使用双参数弹性模型和四参数开尔文粘弹性模型来分析在模拟体内动力学的条件下体外获得的血管直径和血压的实验测量结果。弹性和粘弹性墙体属性通过相关反问题的解来评估。我们使用灵敏度分析来对模型参数进行从最敏感到最不敏感的排序，以及计算标准误差和可信区间。结果表明，两种模型的弹性性质(包括杨氏模数和粘弹性松弛参数)因位置不同而不同(较小的动脉比较大的动脉僵硬)。我们还表明，对于所有位置，粘弹性行为的包含对于捕捉压力-面积动力学是重要的。
In this paper, we analyze how elastic and viscoelastic properties differ across seven locations along the large arteries in 11 sheep. We employ a two-parameter elastic model and a four-parameter Kelvin viscoelastic model to analyze experimental measurements of vessel diameter and blood pressure obtained in vitro at conditions mimicking in vivo dynamics. Elastic and viscoelastic wall properties were assessed via solutions to the associated inverse problem. We use sensitivity analysis to rank the model parameters from the most to the least sensitive, as well as to compute standard errors and confidence intervals. Results reveal that elastic properties in both models (including Young's modulus and the viscoelastic relaxation parameters) vary across locations (smaller arteries are stiffer than larger arteries). We also show that for all locations, the inclusion of viscoelastic behavior is important to capture pressure-area dynamics.