A Meta-Analysis of Interleukin-10-1082 Promoter Polymorphism Associated with Gastric Cancer Risk
A Meta-Analysis of Interleukin-10-1082 Promoter Polymorphism Associated with Gastric Cancer Risk
复制标题
Interleukin-10-1082 启动子多态性与胃癌风险相关的荟萃分析
DOI：
10.1089/dna.2011.1440
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发表时间：
2012-04-01
影响因子：
3.1
通讯作者：
Lu, Yang
中科院分区：
文献类型：
--
作者：
Ni, Peihua;Xu, Hong;Lu, Yang
我们旨在通过系统评价和荟萃分析，探究白细胞介素10（IL - 10）基因启动子 - 1082位点的A/G单核苷酸多态性（SNP）在胃癌易感性中的作用。对最初纳入的每篇文章进行质量评估打分。提取所需数据并录入数据库。最终有20项研究符合纳入IL - 10 - 1082 A/G SNP荟萃分析的标准。我们采用最可能合适的遗传模型（显性模型），即GG + GA基因型合并组与AA基因型进行比较。通过亚组分析和敏感性分析探寻异质性的潜在来源，并评估发表偏倚。在IL - 10 - 1082 GG + GA基因型与患胃癌风险之间，发现与总体胃癌存在统计学显著关联，主要体现在亚洲亚组、大样本亚组、高质量亚组、肠型亚组、贲门型亚组以及部分基因分型方法亚组中。我们的荟萃分析表明，IL - 10 - 1082 GG + GA基因型与患总体胃癌的风险相关，且在亚洲人群中似乎对总体胃癌更具易感性。IL - 10 - 1082 GG + GA基因型与病理上的肠型胃癌或解剖学上的贲门型胃癌关联更为密切。
We aimed to explore the role of allele A/G single nucleotide polymorphism (SNP) of gene Interleukin 10 (IL-10) promoter-1082 in the susceptibility to gastric cancer through a systematic review and meta-analysis. Each initially included article was scored for quality appraisal. Desirable data were extracted and registered into databases. Twenty studies were ultimately eligible for the meta-analysis of IL-10-1082 A/G SNP. We adopted the most probably appropriate genetic model (dominant model), with the combined group of GG-plus-GA genotypes compared with the AA genotype. Potential sources of heterogeneity were sought out via subgroup analyses and sensitivity analyses, and publication biases were estimated. Between IL-10-1082 GG-plus-GA genotypes with the risk of developing gastric cancer, statistically significant association could be noted with overall gastric cancer, being mainly in Asian subgroup, large sample subgroup, high quality subgroup, intestinal-type subgroup, cardia-type subgroup, and some genotyping method subgroups. Our meta-analysis indicates that IL-10-1082 GG-plus-GA genotypes are associated with the overall risk of developing gastric cancer and seem to be more susceptible to overall gastric cancer in Asian populations. IL-10-1082 GG-plus-GA genotypes are more associated with the pathologically intestinal-type gastric cancer or anatomically cardia-type gastric cancer.