Nonlinear temporal dynamics of the cerebral blood flow response
Nonlinear temporal dynamics of the cerebral blood flow response
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DOI：
10.1002/hbm.1020
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发表时间：
2001-05-01
影响因子：
4.8
通讯作者：
Buxton, RB
中科院分区：
文献类型：
--
作者：
Miller, KL;Luh, WM;Buxton, RB
脑灌注反应相对于刺激持续时间的线性是表征局部脑血流量（CBF）、脑代谢和血氧水平依赖性（BOLD）信号之间关系的重要考虑因素。它也是功能神经影像研究设计和分析的关键组成部分。为了研究 CBF 对不同持续时间刺激的响应的线性，使用动脉自旋标记技术和磁共振成像 (A IRI) 测量刺激期间初级运动和视觉皮层的灌注响应，该技术允许同时测量 CBF 和 BOLD 变化。在每项研究中，测量持续 2、6 和 18 秒的刺激的灌注反应。研究发现 CBF 反应通常与刺激持续时间呈非线性相关，尽管运动皮层和视觉皮层之间的非线性强度有所不同。相比之下，我们发现 BOLD 响应在研究的两个区域中都具有很强的非线性，这与之前的发现一致。观察到的非线性与具有从刺激到神经活动的非线性步骤、从神经活动到 CBF 变化的线性步骤以及从 CBF 变化到 BOLD 信号变化的非线性步骤的模型一致。哼。脑图谱 13:1-12, 2001。(C) 2001 Wiley-Liss, Inc.
The linearity of the cerebral perfusion response relative to stimulus duration is an important consideration in the characterization of the relationship between regional cerebral blood flow (CBF), cerebral metabolism, and the blood oxygenation level dependent (BOLD) signal. It is also a critical component in the design and analysis of functional neuroimaging studies. To study the linearity of the CBF response to different duration stimuli, the perfusion response in primary motor and visual cortices was measured during stimulation using an arterial spin labeling technique with magnetic resonance imaging (A IRI) that allows simultaneous measurement of CBF and BOLD changes. In each study, the perfusion response was measured for stimuli lasting 2, 6, and 18 sec. The CBF response was found in general to be nonlinearly related to stimulus duration, although the strength of nonlinearity varied between the motor and visual cortices. In contrast, the BOLD response was found to be strongly nonlinear in both regions studied, in agreement with previous findings. The observed nonlinearities are consistent with a model with a nonlinear step from stimulus to neural activity, a linear step from neural activity to CBF change, and a nonlinear step from CBF change to BOLD signal change. Hum. Brain Mapping 13:1-12, 2001. (C) 2001 Wiley-Liss, Inc.