A norsesquiterpene lactone and a benzoic acid derivative from the leaves of cyclocarya paliurus and their glucosidase and glycogen phosphorylase inhibiting activites
A norsesquiterpene lactone and a benzoic acid derivative from the leaves of cyclocarya paliurus and their glucosidase and glycogen phosphorylase inhibiting activites
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DOI：
10.1055/s-2008-1034309
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发表时间：
2008-02-01
期刊：
影响因子：
2.7
通讯作者：
Lin, Yongcheng
中科院分区：
文献类型：
--
作者：
Li, Jun;Lu, Yuanyuan;Lin, Yongcheng
从青钱柳（Cyclocarya paliurus（Batal.）lljinsk，以及9种已知化合物：蝶内酯（3）、没食子酸（4）、4-羟基-3-甲氧基苯甲酸（5）、油酸（6）、β-乳香酸（7）、α-乳香酸（8）、β-香树脂醇（9）、β-香树脂酮（10）和3 β-O-反式-咖啡酰-morolic acid（111）。结构解析基于光谱方法，包括二维NMR实验（H-1-H-1 COSY、HMQC和HMBC）。所有分离的化合物进行了评价，其糖苷酶和糖原磷酸化酶抑制活性。2-氨基-3，4-二羟基-5-甲氧基苯甲酸和没食子酸具有显著的α-葡萄糖苷酶和糖原磷酸化酶抑制活性。
Two novel compounds, 3-methoxypterolactone (1) and 2-amino-3,4-dihydroxy-5-methoxybeiizoic acid (2), were isolated from leaves of Cyclocarya paliurus (Batal.) lljinsk, together with nine known compounds: pterolactone (3), gallic acid (4), 4-hydroxy-3-methoxybenzoic acid (5), oleanolic acid (6), P-boswellic acid (7), a-boswellic acid (8), beta-amyrin (9), beta-amyrone (10) and 3 beta-O-trans-caffeoyl-morolic acid (111). The structure elucidation was based on spectroscopic methods, including two-dimensional NMR experiments (H-1-H-1 COSY, HMQC and HMBC). All isolated compounds were evaluated for their glycosidase and glycogen phosphorylase inhibitory activities. 2-Amino-3,4-dihydroxy-5-methoxybenzoic acid and gallic acid showed significant a-glucosidase and glycogen phosphorylase inhibitory activities.