Reinnervation of murine muscle following fetal sciatic nerve transection.
Reinnervation of murine muscle following fetal sciatic nerve transection.
复制标题
胎儿坐骨神经横断后小鼠肌肉的神经再支配。
DOI：
10.1002/neu.480220902
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Ontell,M
中科院分区：
文献类型：
--
作者：
Mallonga,RL;Ontell,M
A technique is reproted that permits transection of the sciatic nerve of mouse fetuses without interfering with fetal viability. Sciaticotomy was performed on Swiss Webster mice at day 17 of gestation; the contralateral side served as a control. Six weeks later the extensor digitorum longus (EDL) muscles on both sides were injected with horseradish peroxidase (HRP). Examination of the lumbar spinal cord revealed that while a substantial number of motor neurons in the region of the spinal cord giving rise to the sciatic nerve died, the EDL muscle did become reinnervated. The size of the EDL motor neuron pool on the denervated‐reinnervated side was ∼43% of that seen on the control side. While the control EDL motor neuron pool was located in lumbar segments L3–L5, the location of the pool to the denervated‐reinnervated EDL was shifted cranially to L2–L4. Denervated‐reinnervated EDL muscles were analyzed immunohistochemically to study the effect of fetal denervation on the neuronal cell adhesion molecule (N‐CAM) expression. At 2 weeks postnatal, N‐CAM immunoreactivity in control muscle was segregated to the motor end plate region, while fetally denervated muscle continued to express N‐CAM along the length of the sarcolemma. Thus fetally denervated muscle does not develop the same pattern of N‐CAM expression as normal, innervated muscle. By 6 weeks of age, the denervated‐reinnervated muscle showed the same level and distribution of N‐CAM immunoreactivity as did age‐matched control muscle, indicating that most, if not all, of its myofibers had been reinnervated.
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