A measure of striatal function predicts motor stereotypy
A measure of striatal function predicts motor stereotypy
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DOI：
10.1038/73949
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发表时间：
2000-04-01
影响因子：
25
通讯作者：
Graybiel, AM
中科院分区：
文献类型：
--
作者：
Canales, JJ;Graybiel, AM
为了确定基底神经节回路功能障碍，可能会产生重复的行为称为运动刻板，我们应用精神兴奋剂和直接多巴胺受体激动剂，以诱导大鼠不同程度的刻板。然后，我们使用基因诱导测定来测量纹状体、纹状体和纹状体外基质的神经化学上不同的隔室中的神经元的功能激活。纹状体中的激活超过基质中的激活的量预测了药物治疗诱导的运动刻板症的程度。这些结果表明，分区组织的基底神经节电路之间的不平衡可能代表了运动刻板症的神经相关。
To identify basal ganglia circuit dysfunctions that might produce repetitive behaviors known as motor stereotypies, we applied psychomotor stimulants and a direct dopamine receptor agonist to induce different levels of stereotypy in rats. We then used a gene induction assay to measure the functional activation of neurons in the neurochemically distinct compartments of the striatum, the striosomes and the extrastriosomal matrix. The amount by which activation in the striosomes exceeded activation in the matrix predicted the degree of motor stereotypy induced by the drug treatments. These results suggest that imbalance between compartmentally organized basal ganglia circuits may represent a neural correlate of motor stereotypy.