Androgen receptor roles in spermatogenesis and infertility
Androgen receptor roles in spermatogenesis and infertility
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DOI：
10.1016/j.beem.2015.04.006
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发表时间：
2015-08-01
影响因子：
7.4
通讯作者：
Smith, Lee B.
中科院分区：
文献类型：
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作者：
O'Hara, Laura;Smith, Lee B.
雄激素，如睾酮是类固醇激素，对正常的男性生殖发育和功能至关重要。雄激素受体（AR）的突变经常在男性生殖发育障碍患者中发现，轻度突变可能是导致某些男性不育的原因。雄激素通过AR发挥作用，其在睾丸中的信号传导对精子发生至关重要。AR在发育中的生殖细胞谱系中不表达，因此被认为通过睾丸支持细胞和笔管肌样细胞（PTM）发挥其作用。已在睾酮水平被化学抑制的啮齿动物模型或AR转基因破坏模型中研究了精子发生中的AR信号传导。这些模型已经确定了精子发生的步骤，需要AR信号，特别是维持精原细胞数量，血-睾丸屏障的完整性，完成减数分裂，精子细胞的粘附和精子形成，这些研究一起详细说明了雄激素在促进男性生育力中的基本性质。(C)2015作者爱思唯尔有限公司出版
Androgens such as testosterone are steroid hormones essential for normal Male reproductive development and function. Mutations of androgen receptors (AR) are often found in patients with disorders of male reproductive development, and milder mutations may be responsible for some cases of male infertility. Androgens exert their action through AR and its signalling in the testis is essential for spermatogenesis. AR is not expressed in the developing germ cell lineage so is thought to exert its effects through testicular Sertoli and pen-tubular myoid (PTM) cells. AR signalling in spermatogenesis has been investigated in rodent models where testosterone levels are chemically supressed or models with transgenic disruption of AR. These models have pinpointed the steps of spermatogenesis that require AR signalling, specifically maintenance of spermatogonial numbers, blood-testis barrier integrity, completion of meiosis, adhesion of spermatids and spermiation, together these studies detail the essential nature of androgens in the promotion of male fertility. (C) 2015 The Authors. Published by Elsevier Ltd.