Effect of fatty acids on phase behavior of hydrated dipalmitoylphosphatidylcholine bilayer: saturated versus unsaturated fatty acids
Effect of fatty acids on phase behavior of hydrated dipalmitoylphosphatidylcholine bilayer: saturated versus unsaturated fatty acids
复制标题
DOI：
10.1016/s0009-3084(00)00170-5
复制
发表时间：
2001-02-01
影响因子：
3.4
通讯作者：
Suzuki, M
中科院分区：
文献类型：
--
作者：
Inoue, T;Yanagihara, S;Suzuki, M
研究了一些脂肪酸对水合二棕榈酰磷脂酰胆碱 (DPPC) 双层相行为的影响，特别关注饱和脂肪酸和不饱和脂肪酸之间可能存在的差异。通过差示扫描量热法和傅里叶变换红外光谱分析水合 DPPC 双层的相行为。随着混合物中PA含量的增加，棕榈酸（PA）的添加提高了双层相变温度。此外，与不存在 PA 的情况相比，存在 PA 的情况下，凝胶相双层中的 DPPC 分子变得更加刚性。 PA 对水合 DPPC 双层相行为的这种影响对于其他饱和脂肪酸、硬脂酸、肉豆蔻酸以及具有反式双键的不饱和脂肪酸来说是常见的。反油酸。与这些脂肪酸相反，油酸（OA），酰基链中带有 cb 双键的不饱和脂肪酸，表现出完全不同的行为。 OA 对双层相变温度的影响相当小，尽管温度略有下降：是明显的。此外，红外光谱结果表明，OA对DPPC凝胶相双层的干扰作用很小。这些结果意味着 OA 不会显着干扰水合 DPPC 双层。 (C) 2001 Elsevier Science Ireland Ltd. 保留所有权利。
The effect of some fatty acids on the phase behavior of hydrated dipalmitoylphosphatidylcholine (DPPC) bilayer was investigated with special interest in possible difference between saturated and unsaturated fatty acids. The phase behavior of hydrated DPPC bilayer was followed by a differential scanning calorimetry and a Fourier transform infrared spectroscopy. The addition of palmitic acid (PA) increased the bilayer phase transition temperature with the increase of the PA content in the mixture. In addition, DPPC molecules in gel phase bilayer became more rigid in the presence of PA compared with those in the absence of PA. This effect of PA on the phase behavior of hydrated DPPC bilayer is common to other saturated fatty acids, stearic acid, myristic acid, and also to unsaturated fatty acid with trans double bond. elaidic acid. Contrary to these fatty acids, oleic acid (OA), the unsaturated fatty acid with cb double bond in the acyl chain, exhibited quite different behavior. The effect of OA on the bilayer phase transition temperature was rather small, although a slight decrease ill the temperature: was appreciable. Furthermore, the IR spectral results demonstrated that the perturbing effect of OA on the gel phase bilayer of DPPC was quits small. These results mean that OA does not disturb the hydrated DPPC bilayer significantly. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.