Sense of control, selective attention and cognitive inhibition in pediatric functional seizures: A prospective case-control study.
Sense of control, selective attention and cognitive inhibition in pediatric functional seizures: A prospective case-control study.
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DOI：
10.1016/j.seizure.2022.03.021
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发表时间：
2022-05
影响因子：
3
通讯作者：
Fobian, Aaron D.
中科院分区：
文献类型：
--
作者：
Stager, Lindsay;Morriss, Skylar;McKibben, Lauren;Grant, Merida;Szaflarski, Jerzy P.;Fobian, Aaron D.
关键词：
迄今为止，基于实验室的实验行为方法尚未用于确定与儿童功能性癫痫发作（FS）相关的因素，这为有效治疗的开发留下了关键空白。根据收入、性别、种族和年龄，将经视频脑电图确认的 FS 的 13-18 岁儿童与对照组 (MC) 进行匹配。修改后的斯特鲁普任务包括一个条件，要求参与者报告癫痫症状词所用的墨水颜色（例如，蓝色的“颤抖”），通过反应时间测量选择性注意力和认知抑制。魔法和湍流任务评估了三种条件（魔法、滞后、湍流）下的控制感。患有 FS 的儿童被要求报告预测 FS 的先兆症状。参与者包括 26 名 FS 儿童和 26 名 MC 儿童（平均年龄 = 15.2，74% 为女性，59% 为白人）。在 Stroop 上，FS 儿童对癫痫症状词的反应时间（平均值 = 1193.83）比 MC 儿童（平均值 = 949.26，p = 0.022）慢。 FS儿童在魔法和湍流任务的湍流条件下的控制感（平均值=−3.99，SD=8.83）明显低于MC儿童（平均值=−11.51，SD=7.87；t（20）=−2.61，p=0.017）。 FS 儿童（平均值=−1.80，SD=6.54）在魔法条件下的控制感也明显低于 MC 儿童（平均值=−5.57，SD=6.01；p=0.028）。百分之九十八的患者认可先兆症状。与 MC 相比，患有 FS 的儿童 1）在呈现癫痫相关信息时选择性注意和认知抑制较差，2）控制感较低（即对自己的控制被操纵的认识较差）。预兆症状很常见。控制感、选择性注意和抑制可能是 FS 干预的新治疗目标。
To date, laboratory-based experimental behavioral methods have not been used to identify factors associated with pediatric functional seizures (FS), leaving a critical gap for effective treatment development. Children ages 13–18 with video-EEG-confirmed FS were matched to controls (MCs) based on income, sex, race, and age. A modified Stroop task which included a condition requiring participants to report the ink colors in which seizure symptom words were written (e.g., “shaking” in blue) measured selective attention and cognitive inhibition through response time. The magic and turbulence task assessed sense of control in three conditions (magic, lag, turbulence). Children with FS were asked to report premonitory symptoms predicting FS. Participants included 26 children with FS and 26 MCs (Meanage=15.2, 74% female, 59% white). On Stroop, children with FS had a slower reaction time (Mean=1193.83) than MCs (Mean=949.26, p=0.022) for seizure symptom words. Children with FS had significantly poorer sense of control in the turbulence condition of the magic and turbulence task (Mean=−3.99, SD=8.83) than MCs (Mean=−11.51, SD=7.87; t(20)= −2.61, p=0.017). Children with FS (Mean=−1.80, SD=6.54) also had significantly poorer sense of control in the magic condition than MCs (Mean=−5.57, SD=6.01; p=0.028). Ninety-eight percent of patients endorsed premonitory symptoms. Compared with MCs, children with FS have 1) poorer selective attention and cognitive inhibition when presented with seizure-related information and 2) lower sense of control (i.e. poorer awareness that their control was manipulated). Premonitory symptoms were common. Sense of control, selective attention, and inhibition may be novel treatment targets for FS intervention.
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影响因子：
--
作者：
Kozlowska K;Sawchuk T;Waugh JL;Helgeland H;Baker J;Scher S;Fobian AD
通讯作者：
Fobian AD
影响因子：
2.6
作者：
Edwards, Mark J.;Moretto, Giovanna;Haggard, Patrick
通讯作者：
Haggard, Patrick
影响因子：
1.8
作者：
Kozlowska K;Chudleigh C;Cruz C;Lim M;McClure G;Savage B;Shah U;Cook A;Scher S;Carrive P;Gill D
通讯作者：
Gill D
影响因子：
--
作者：
Fobian AD;Szaflarski JP
通讯作者：
Szaflarski JP
影响因子：
25
作者：
Haggard, P;Clark, S;Kalogeras, J
通讯作者：
Kalogeras, J