Influence of poly(N-isopropylacrylamide) and poly(N,N′-diethyl acrylamide) coatings on polysulfone/polyacrylonitrile-based membranes for protein separation
Influence of poly(N-isopropylacrylamide) and poly(N,N′-diethyl acrylamide) coatings on polysulfone/polyacrylonitrile-based membranes for protein separation
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DOI：
10.1002/pat.2057
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发表时间：
2012-10
影响因子：
3.4
通讯作者：
Telma Barroso;R. Viveiros;M. Coelho;T. Casimiro;A. Rego;A. Aguiar-Ricardo
中科院分区：
文献类型：
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作者：
Telma Barroso;R. Viveiros;M. Coelho;T. Casimiro;A. Rego;A. Aguiar-Ricardo
在此，我们描述了使用超临界流体技术的温度敏感聚砜（PS）/聚丙烯腈（PAN）共混膜的设计和组装。采用CO2辅助相转化法制备了共混膜，其孔内涂覆了两种热响应性水凝胶——聚(N-异丙基丙烯酰胺)(PNIPAAm)和聚(N,N'-二乙基丙烯酰胺)(PDEAAm)。使用牛血清白蛋白（BSA）和溶菌酶（LYS）溶液的渗透实验来评估涂层膜的性能和温度响应行为。虽然涂有 PNIPAAm 的膜在低于和高于其较低临界溶液温度的温度下表现出相似的蛋白质渗透曲线，但 PDEAAm 涂层赋予 PS/PAN (90:10) 膜温度响应行为，并选择性地渗透不同尺寸的蛋白质。版权所有 © 2011 约翰·威利父子有限公司
Herein we describe the design and the assembly of temperature sensitive polysulfone (PS)/polyacrylonitrile (PAN) blend membranes using supercritical fluid technology. Blended membranes were prepared using the CO2-assisted phase inversion method, and their pores were coated with two thermoresponsive hydrogels-poly(N-isopropylacrylamide) (PNIPAAm) and poly(N,N′-diethylacrylamide) (PDEAAm). Permeation experiments of bovine serum albumin (BSA) and lysozyme (LYS) solutions were used to evaluate the performance and temperature-responsive behavior of coated membranes. While membranes coated with PNIPAAm presented similar protein permeation profiles at temperatures below and above its lower critical solution temperature, PDEAAm coating imparted a temperature-responsive behavior to PS/PAN (90:10) membranes and selective permeation of proteins with different sizes. Copyright © 2011 John Wiley & Sons, Ltd.