Unique properties of mesoprefrontal neurons within a dual mesocorticolimbic dopamine system
Unique properties of mesoprefrontal neurons within a dual mesocorticolimbic dopamine system
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DOI：
10.1016/j.neuron.2008.01.022
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发表时间：
2008-03-13
期刊：
影响因子：
16.2
通讯作者：
Roeper, Jochen
中科院分区：
文献类型：
--
作者：
Lammel, Stephan;Hetzel, Andrea;Roeper, Jochen
中皮质边缘多巴胺系统对于认知和情感脑功能是必不可少的，因此是主要脑疾病如精神分裂症、药物成瘾和注意缺陷多动障碍的重要靶点。然而，中皮质边缘系统内行为功能和相关多巴胺释放模式多样性的细胞基础仍不清楚。在这里，我们报告的一种类型的多巴胺能神经元内的mesocorticolimbic多巴胺系统与非常规的快速放电特性和小DAT/TH mRNA的表达比例，选择性地项目，以前额皮质和核的核心和内侧壳，以及基底外侧杏仁核。相比之下，描述良好的传统慢放电多巴胺中脑神经元只投射到外侧壳核和背外侧纹状体。在这项研究中定义的双重多巴胺中脑系统中，通过会聚解剖学，电生理学和分子特性，中前额叶多巴胺能神经元是独特的，因为只有它们不具有功能性体树突Girk 2偶联多巴胺D2自身受体。
The mesocorticolimbic dopamine system is essential for cognitive and emotive brain functions and is thus an important target in major brain diseases like schizophrenia, drug addiction, and attention deficit hyperactivity disorder. However, the cellular basis for the diversity in behavioral functions and associ- ated dopamine-release pattern within the mesocorticolimbic system has remained unclear. Here, we report the identification of a type of dopaminergic neuron within the mesocorticolimbic dopamine system with unconventional fast-firing properties and small DAT/TH mRNA expression ratios that selectively projects to prefrontal cortex and nucleus accumbens core and medial shell as well as to basolateral amygdala. In contrast, well-described conventional slow-firing dopamine midbrain neurons only project to the lateral shell of the nucleus accumbens and the dorsolateral striatum. Among this dual dopamine midbrain system defined in this study by converging anatomical, electrophysiological, and molecular properties, mesoprefrontal dopaminergic neurons are unique, as only they do not possess functional somatodendritic Girk2-coupled dopamine D2 autoreceptors.