Transposase-derived transcription factors regulate light signaling in Arabidopsis
Transposase-derived transcription factors regulate light signaling in Arabidopsis
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DOI：
10.1126/science.1146281
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发表时间：
2007-11-23
期刊：
影响因子：
56.9
通讯作者：
Wang, Haiyang
中科院分区：
文献类型：
--
作者：
Lin, Rongcheng;Ding, Lei;Wang, Haiyang
植物利用光来优化生长和发育。光感受器光敏色素A （phyA）介导各种远红光诱导反应。我们发现拟南芥FHY3和FAR1编码两种与Mutator-like转座酶相关的蛋白，它们通过直接激活FHY1和FHL的转录来共同调节phyA信号，FHY1和FHL的产物是光诱导phyA核积累和随后的光响应所必需的。FHY3和FAR1具有可分离的DNA结合和转录激活结构域，这些结构域在突变样转座中高度保守。此外，FHY3和FAR1的表达受到phyA信号传导的负调控。我们认为FHY3和FAR1代表了一种古老的类突变转座酶（Mutator-like transpoase）的转录因子，可以调节高等植物的植物信号稳态。
Plants use light to optimize growth and development. The photoreceptor phytochrome A ( phyA) mediates various far-red light-induced responses. We show that Arabidopsis FHY3 and FAR1, which encode two proteins related to Mutator-like transposases, act together to modulate phyA signaling by directly activating the transcription of FHY1 and FHL, whose products are essential for light-induced phyA nuclear accumulation and subsequent light responses. FHY3 and FAR1 have separable DNA binding and transcriptional activation domains that are highly conserved in Mutator-like transposases. Further, expression of FHY3 and FAR1 is negatively regulated by phyA signaling. We propose that FHY3 and FAR1 represent transcription factors that have been co-opted from an ancient Mutator-like transposase(s) to modulate phyA-signaling homeostasis in higher plants.