Sirtuin 1 attenuates oxidative stress via upregulation of superoxide dismutase 2 and catalase in astrocytes
Sirtuin 1 attenuates oxidative stress via upregulation of superoxide dismutase 2 and catalase in astrocytes
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DOI：
10.1016/j.jneuroim.2014.02.001
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发表时间：
2014-04-15
影响因子：
3.3
通讯作者：
Suzumura, Akio
中科院分区：
文献类型：
--
作者：
Cheng, Yi;Takeuchi, Hideyuki;Suzumura, Akio
Sirtuin 1 （SIRT1）对多种神经系统疾病具有神经保护作用。我们研究了SIRT1在星形胶质细胞中的保护功能，星形胶质细胞是中枢神经系统中最丰富的细胞。上调SIRT1抑制促炎细胞毒素的表达水平，增加超氧化物歧化酶2和过氧化氢酶的表达水平。相反，抑制SIRT1显著增加叉头盒蛋白04的乙酰化，降低超氧化物歧化酶2和过氧化氢酶的表达水平，并增加。活性氧的产生。我们的数据表明星形细胞SIRT1可能通过其抗氧化和抗炎功能引起神经保护作用。(C) 2014 Elsevier B.V.版权所有
Sirtuin 1 (SIRT1) exerts a neuroprotective effect on various neurologic diseases. Here we investigated the protective functions of SIRT1 in astrocytes, which are the most abundant cells in the central nervous system. Upregulation of SIRT1 suppressed the expression levels of pro-inflammatory cytolcines and increased the expression levels of superoxide dismutase 2 and catalase. Inversely, inhibition of SIRT1 significantly increased the acetylation of forkhead box protein 04, decreased the expression levels of superoxide dismutase 2 and catalase, and increased. the production of reactive oxygen species. Our data suggest that astrocytic SIRT1 may elicit neuroprotective effects through its anti-oxidative and anti-inflammatory functions. (C) 2014 Elsevier B.V. All rights reserved.