Partial reduction of blood pressure and prevention of complications in hypertension.
Partial reduction of blood pressure and prevention of complications in hypertension.
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部分降低血压并预防高血压并发症。
DOI：
10.1056/nejm197408152910703
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发表时间：
1974
期刊：
影响因子：
--
通讯作者：
E. Freis
中科院分区：
文献类型：
--
作者：
J. Taguchi;E. Freis
本文分析了退伍军人管理合作研究中对随机前舒张压平均为90~114 mm Hg的患者所获得的数据，以确定将血压降至正常在预防重大并发症中的重要性。在380名患者中，186人被随机分配到积极药物治疗组。根据随机化4个月后访问时记录的血压来选择两个亚组的治疗患者：A亚组包括67名舒张压在90 mm Hg或更高的患者，而B亚组包括62名舒张压在80 mm Hg或更低的患者。在平均3.2年的随访期内，A亚组14.9%和B亚组9.7%的患者发生心血管并发症。A亚组的发病率显著低于未治疗组的28.9%。结果表明，尽管血压正常化...
Abstract The data obtained in the Veterans Administration Cooperative Study on patients with prerandomization diastolic blood pressures averaging 90 to 114 mm Hg were analyzed to ascertain the importance of reducing blood pressure to normal in prevention of major complications. Of 380 patients 186 were randomly assigned to active drug treatment. Blood pressures recorded at the visit four months after randomization were used to select two subgroups of treated patients: Subgroup A comprised 67 patients who exhibited diastolic blood pressures of 90 mm Hg or higher, whereas Subgroup B included 62 patients with diastolic levels of 80 mm Hg or less. Over an average follow-up period of 3.2 years cardiovascular complications developed in 14.9 per cent of Subgroup A and 9.7 per cent of Subgroup B. The attack rates in Subgroup A were significantly less (p<0.05) than the 28.9 per cent of patients in the untreated group in whom morbid events developed. The results suggest that although normalization of blood pressure...