Robust Subthreshold Cross-modal Modulation of Auditory Response by Cutaneous Electrical Stimulation in First- and Higher-order Auditory Thalamic Nuclei
Robust Subthreshold Cross-modal Modulation of Auditory Response by Cutaneous Electrical Stimulation in First- and Higher-order Auditory Thalamic Nuclei
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DOI：
10.1016/j.neuroscience.2017.12.051
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发表时间：
2018-02
期刊：
影响因子：
3.3
通讯作者：
A. Kimura;H. Imbe
中科院分区：
文献类型：
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作者：
A. Kimura;H. Imbe
常规的细胞外记录已经揭示了通过对后爪的皮肤电刺激在第一级和高级听觉丘脑核中的听觉细胞活动的交叉模式改变（Donishi等人，2011年）。在本研究中使用近细胞记录和标记技术来详细检查跨模态的改变，重点关注可能的核和/或细胞类型相关的区别调制。从麻醉大鼠的80个细胞中获得记录。皮肤电刺激，未引起单位放电，即，阈下效应，第一（64%）和高级核细胞（77%）的调制早期（发作）和/或晚期听觉反应的反应幅度，潜伏期和/或突发尖峰。衰减在响应幅度和爆发性尖峰的调制中占主导地位，延迟在响应时间的调制中占主导地位。爆发尖峰的显著变化发生在高阶核细胞中，与一阶核细胞相比，高阶核细胞有可能表现出更高的爆发尖峰倾向。一个亚群的一阶核细胞显示调制的早期反应幅度在尾域的核有较大的细胞体和更高的倾向爆发尖峰相比，没有调制的细胞。这些发现表明，体感的影响被纳入听觉丘脑核团的平行通道，施加不同的影响皮层和皮层下的感觉处理。此外，皮肤电刺激后，早期听觉反应调制迟发反应。躯体感觉的影响很可能会影响正在进行的听觉处理在任何时候，而不是在一个狭窄的时间窗口与声音开始一致。
Conventional extracellular recording has revealed cross-modal alterations of auditory cell activities by cutaneous electrical stimulation of the hindpaw in first- and higher-order auditory thalamic nuclei (Donishi et al., 2011). Juxta-cellular recording and labeling techniques were used in the present study to examine the cross-modal alterations in detail, focusing on possible nucleus and/or cell type-related distinctions in modulation. Recordings were obtained from 80 cells of anesthetized rats. Cutaneous electrical stimulation, which did not elicit unit discharges, i.e., subthreshold effects, modulated early (onset) and/or late auditory responses of first- (64%) and higher-order nucleus cells (77%) with regard to response magnitude, latency and/or burst spiking. Attenuation predominated in the modulation of response magnitude and burst spiking, and delay predominated in the modulation of response time. Striking alterations of burst spiking took place in higher-order nucleus cells, which had the potential to exhibit higher propensities for burst spiking as compared to first-order nucleus cells. A subpopulation of first-order nucleus cells showing modulation in early response magnitude in the caudal domain of the nucleus had larger cell bodies and higher propensities for burst spiking as compared to cells showing no modulation. These findings suggest that somatosensory influence is incorporated into parallel channels in auditory thalamic nuclei to impose distinct impacts on cortical and subcortical sensory processing. Further, cutaneous electrical stimulation given after early auditory responses modulated late responses. Somatosensory influence is likely to affect ongoing auditory processing at any time without being coincident with sound onset in a narrow temporal window.