RAPID CHANGES OF OPTICAL-PARAMETERS IN THE HUMAN BRAIN DURING A TAPPING TASK
RAPID CHANGES OF OPTICAL-PARAMETERS IN THE HUMAN BRAIN DURING A TAPPING TASK
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DOI：
10.1162/jocn.1995.7.4.446
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发表时间：
1995-09-01
影响因子：
3.2
通讯作者：
GRATTON, E
中科院分区：
文献类型：
--
作者：
GRATTON, G;FABIANI, M;GRATTON, E
通过头部的近红外光子的迁移参数的措施（衰减，或强度，和飞行时间，或延迟）已被提出作为一种非侵入性的评估方式，并在一个准连续的方式在脑组织的散射和吸收特性的变化。反过来，这些可能反映了与行为任务相关的功能变化。为了验证这一假设，我们测量了四名人类受试者运动皮质附近头皮位置的光子迁移参数的变化，用左手或右手、左脚或右脚以0.8 Hz的频率敲击。敲击产生慢效果（需要几秒钟）和快效果（跟踪敲击频率）。慢效应的特点是增加和延迟的光通过半球对侧的轻敲的手。快速效应包括手敲击过程中光延迟的变化。基于大脑分层模型的蒙特卡罗模拟表明，快速效应与头部深层（可能在皮层）的变化一致，而缓慢效应与吸收材料向深层的转移或散射的减少一致。这些结果表明，光学参数可以监测大脑活动的快速变化，与运动皮层的对侧组织相匹配。
Measures of parameters of the migration of near-infrared photons through the head (attenuation, or intensity, and time-of-flight, or delay) have been proposed as a way of assessing noninvasively and in a quasicontinuous fashion changes in the scattering and absorption properties of brain tissue. These, in turn, may reflect functional changes associated with behavioral tasks. To test this hypothesis, we measured changes of photon migration parameters from scalp locations proximal to the motor cortex from four human subjects, tapping at a rate of 0.8 Hz with their left or right hand, or with their left or right foot. Tapping produced both slow effects (requiring several seconds) and fast effects (tracking the tapping frequency). Slow effects were characterized by increase and delay of the light passing through the hemisphere contralateral to the tapping hand. Fast effects consisted of changes in the light delay during hand tapping. Monte Carlo simulations based on layer models of the brain indicated that fast effects are consistent with changes in deep layers of the head (presumably in the cortex), and that slow effects are consistent with either a shift of absorbing material toward deeper layers or a reduction in scattering. These results suggest that optical parameters can monitor rapid changes of brain activity, matching the contralateral organization of the motor cortex.