18F-FDG PET/CT and 3.0-T whole-body MRI for the detection of distant metastases and second primary tumours in patients with untreated oropharyngeal/hypopharyngeal carcinoma: a comparative study
18F-FDG PET/CT and 3.0-T whole-body MRI for the detection of distant metastases and second primary tumours in patients with untreated oropharyngeal/hypopharyngeal carcinoma: a comparative study
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DOI：
10.1007/s00259-011-1824-y
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发表时间：
2011-09-01
影响因子：
9.1
通讯作者：
Ng, Shu-Hang
中科院分区：
文献类型：
--
作者：
Chan, Sheng-Chieh;Wang, Hung-Ming;Ng, Shu-Hang
目的比较F-18-FDG PET/CT和3.0-T全身MRI（WB-MRI）对未经治疗的口咽或下咽鳞状细胞癌（OHSCC）远处转移和第二原发癌（SPC）的诊断价值。所有参与者均接受了3.0 T WB-MRI和F-18-FDG PET/CT。使用受试者工作特征曲线下面积比较两种成像模式的诊断能力。结果103例患者中，18例（17.5%）发现远处转移或SPC。共涉及21个站点。在基于病变的分析中，F-18-FDG PET/CT显示出比WB-MRI更高的灵敏度趋势（81.0% vs. 61.9%，P = 0.125）。PET/CT的曲线下面积（AUC）也高于WB-MRI，但不显著（0.932 vs. 0.866，P = 0.189）。在基于患者的分析中，WB-MRI的灵敏度低于PET/CT（66.7% vs. 83.3%，P = 0.625）。在诊断能力方面，PET/CT的AUC高于WB-MRI（0.886 vs. 0.813，P = 0.355）。结论F18-FDGPET/CT对未治疗的OHSCC患者的远处转移和SPC的检测灵敏度和诊断能力均高于3.0-Tesla WB-MRI。我们的数据还表明，通过PET/CT评估的SUVn可以为预测远处转移提供额外的信息。
Purpose The aim of this prospective study was to compare the diagnostic value of F-18-FDG PET/CT and 3.0-T whole-body MRI (WB-MRI) for the assessment of distant metastases and second primary cancer (SPC) in patients with untreated oropharyngeal or hypopharyngeal squamous cell carcinoma (OHSCC).Methods A total of 103 patients were enrolled. All participants underwent 3.0-T WB-MRI and F-18-FDG PET/CT. The diagnostic capabilities of the two imaging modalities were compared using the area under the receiver-operating-characteristic curve. Histology and follow-up data were used as the reference standard.Results Of the 103 patients, 18 (17.5%) were found to have either distant metastases or SPC. A total of 21 sites were involved. On a lesion-based analysis, F-18-FDG PET/CT showed a trend toward a higher sensitivity than WB-MRI (81.0% vs. 61.9%, P = 0.125). The area under the curve (AUC) for PET/CT was also higher than for WB-MRI, although not significantly so (0.932 vs. 0.866, P = 0.189). On a patient-based analysis, the sensitivity of WB-MRI was lower than that of PET/CT (66.7% vs. 83.3%, P = 0.625). In terms of diagnostic capability, the AUC was higher for PET/CT than WB-MRI (0.886 vs. 0.813, P = 0.355). The maximal SUV of the regional lymph nodes (SUVn) above the median value (8.7 g/ml) was significantly associated with the occurrence of distant metastasis (P = 0.026).Conclusion F-18-FDG PET/CT showed a consistent trend toward higher sensitivity and diagnostic capability than 3.0-Tesla WB-MRI for the detection of distant metastases and SPCs in patients with untreated OHSCC. Our data also suggest that SUVn assessed by PET/CT can provide additional information for the prediction of distant metastases.