Progress and prospects in rat genetics: a community view
Progress and prospects in rat genetics: a community view
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DOI：
10.1038/ng.147
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发表时间：
2008-05-01
期刊：
影响因子：
30.8
通讯作者：
Worley, Kim
中科院分区：
文献类型：
--
作者：
Aitman, Timothy J.;Critser, John K.;Worley, Kim
大鼠是模拟人类疾病的重要系统。四年前，大鼠基因组测序改变了大鼠研究150年的丰富历史，开启了一个为识别疾病表型相关基因和途径提供绝佳机会的时代。人类全基因组关联研究最近为发现常见疾病中强大的遗传关联提供了一种直接方法，但确定精确的基因及其作用机制仍然存在问题。在过去十年中大鼠基因组资源取得重大进展的背景下，我们概述了迄今为止大鼠基因发现的成就，展示了这些发现如何转化为人类疾病，并记录了新疾病基因，途径和机制的发现速度越来越快。最后，我们提出了一套原则，证明继续和加强大鼠模型的遗传研究，并进一步发展大鼠研究的基因组基础设施。
The rat is an important system for modeling human disease. Four years ago, the rich 150-year history of rat research was transformed by the sequencing of the rat genome, ushering in an era of exceptional opportunity for identifying genes and pathways underlying disease phenotypes. Genome-wide association studies in human populations have recently provided a direct approach for finding robust genetic associations in common diseases, but identifying the precise genes and their mechanisms of action remains problematic. In the context of significant progress in rat genomic resources over the past decade, we outline achievements in rat gene discovery to date, show how these findings have been translated to human disease, and document an increasing pace of discovery of new disease genes, pathways and mechanisms. Finally, we present a set of principles that justify continuing and strengthening genetic studies in the rat model, and further development of genomic infrastructure for rat research.