Comparison of early pregnancy and neonatal outcomes after frozen and fresh embryo transfer in ART cycles
Comparison of early pregnancy and neonatal outcomes after frozen and fresh embryo transfer in ART cycles
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DOI：
10.1007/s10815-010-9470-z
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发表时间：
2010-12-01
影响因子：
3.1
通讯作者：
Mohamadian, Farnaz
中科院分区：
文献类型：
--
作者：
Aflatoonian, Abbas;Moghaddam, Fatemeh Mansoori;Mohamadian, Farnaz
目的与新鲜胚胎移植（ET）相比，冷冻胚胎移植（FET）对新生儿结局没有明显的负面影响，其新生儿结局相似甚至更好。本研究的目的是比较FET和新鲜ET后出生的儿童的早期妊娠结局和新生儿健康状况。方法本研究比较FET （n = 200）和新鲜ET （n = 500）后的早期妊娠和新生儿结局。结果对于早期妊娠，FET组和新鲜ET组的生化妊娠具有可比性。FET组自然流产率（14.5%）明显高于新鲜ET组（9%）。除了FET组的活产率（55%）低于新鲜ET组（66%）外，两组之间的新生儿结局具有可比性。结论与新鲜ET相比，FET在早产、低出生体重、死胎、新生儿死亡和重大畸形方面的新生儿结局相似。
Purpose Frozen embryo transfer (FET) has no clear negative impact on neonatal outcome compared with fresh embryo transfer (ET) and appears to result in similar or even better neonatal outcome. The objective of this study was to compare early pregnancy outcome and neonatal health of children born after FET and fresh ET.Methods In this study early pregnancy and neonatal outcomes after FET (n = 200) and fresh ET (n = 500) were compared.Results For early pregnancy, biochemical pregnancy was comparable between FET and fresh ET groups. Spontaneous abortion was significantly higher in FET (14.5%) than fresh ET group (9%). Neonatal outcome was comparable between both groups except for lower live birth rate in FET (55%) versus fresh ET group (66%).Conclusion FET has similar neonatal outcome in terms of prematurity, low birth weight, stillbirth, neonatal death and major malformation compared with fresh ET.