BIOCHEMICAL AND GENETIC-STUDIES ON RABBIT HEMOGLOBIN .1. ELECTROPHORETIC POLYMORPHISM OF THE BETA-CHAIN
BIOCHEMICAL AND GENETIC-STUDIES ON RABBIT HEMOGLOBIN .1. ELECTROPHORETIC POLYMORPHISM OF THE BETA-CHAIN
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DOI：
10.1007/bf02396059
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发表时间：
1989-12-01
影响因子：
2.4
通讯作者：
FERRAND, N
中科院分区：
文献类型：
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作者：
FERRAND, N
通过酸性淀粉凝胶电泳证明了β-链兔(Oryctolagus cuniculus)血红蛋白的遗传多态性。所提供的生化证据表明，先前报道的组氨酸中性氨基酸的取代是检测到的遗传变异的原因。对 15 个交配的 49 个后代的样本进行了分离分析，并证实了遗传假设：常染色体位点上有两个常见的等位基因。在 125 名个体的随机样本中计算出的基因频率为 HBB*1 = 0.48 和 HBB*2 = 0.52。
A genetic polymorphism of .beta.-chain rabbit (Oryctolagus cuniculus) hemoglobin is demonstrated by means of acid starch gel electrophoresis. The biochemical evidence presented suggests that a previously reported substitution of a neutral amino acid for a histidine is responsible for the detected genetic variation. Segregation analysis was performed in a sample of 15 matings with 49 offspring and confirmed the genetic hypothesis: two common alleles at an autosomal locus. The calculated gene frequencies in a random sample of 125 individuals are HBB*1 = 0.48 and HBB*2 = 0.52.