Characterization of ganglionic acetylcholine receptor autoantibodies
Characterization of ganglionic acetylcholine receptor autoantibodies
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DOI：
10.1016/j.jneuroim.2008.03.017
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发表时间：
2008-06-15
影响因子：
3.3
通讯作者：
Low, Phillip A.
中科院分区：
文献类型：
--
作者：
Vernino, Steven;Lindstrom, Jon;Low, Phillip A.
在重症肌无力（MG）中，自身抗体与肌肉烟碱乙酰胆碱受体（AChR）的α 1亚单位和其他亚单位结合。自身免疫性自主神经节病（AAG）是由抗自主神经节中神经元AChR的抗体引起的抗体介导的神经系统疾病。肌肉和神经元AChR的亚基是同源的。我们研究了MG和AAG患者AChR抗体的特异性。在AAG患者中发现的神经节AChR自身抗体对含有α 3亚基的AChR具有特异性。肌肉和神经节AChR抗体特异性是不同的。具有不同α亚基的AChR之间的抗体交叉反应性是不常见的，但可以发生。(C)2008 Elsevier B.V.保留所有权利。
In myasthenia gravis (MG), autoantibodics bind to the alpha 1 subunit and other Subunits of the muscle nicotinic acetylcholine receptor (AChR). Autoimmune autonomic ganglionopathy (AAG) is an anti body-mediated neurological disorder caused by antibodies against neuronal AChRs in autonomic ganglia. Subunits of muscle and neuronal AChR are homologous. We examined the specificity of AChR antibodies in patients with MG and AAG. Ganglionic AChR autoantibodies found in AAG patients are specific for AChRs containing the alpha 3 subunit. Muscle and ganglionic AChR antibody specificities are distinct. Antibody crossreactivity between AChRs with different alpha subunits is uncommon but can occur. (C) 2008 Elsevier B.V. All rights reserved.