Selenium and cardiometabolic health: inconclusive yet intriguing evidence.
Selenium and cardiometabolic health: inconclusive yet intriguing evidence.
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DOI：
10.1097/maj.0b013e3182638716
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发表时间：
2013-09
期刊：
影响因子：
--
通讯作者：
Joseph J
中科院分区：
文献类型：
--
作者：
Joseph J
硒以硒代半胱氨酸的形式存在于硒蛋白中，调节氧化还原平衡等重要的生物学过程。关于血浆硒水平与心脏代谢参数的关系，流行病学和临床研究的结果是不确定的，并且不支持常规使用硒补充剂来预防癌症或心血管疾病。研究人群中硒状态的变异性和缺乏标准化的硒状态测量方法可能是造成硒和心脏代谢健康混淆的部分原因。另一种可能性是，硒蛋白的作用与体内硒代谢产生的低分子量硒化合物的作用不同，这可能解释了实验模型中硒缺乏和过量诱导的相似表型的不寻常现象，并为临床研究缺乏一致性提供了合理的解释。流行病学，临床和实验证据，虽然在硒与心脏代谢健康的确切关系方面没有定论，但是，非常有趣的是，迫切需要进一步的机制研究，使这种有效的微量营养素的临床使用。
Selenium is incorporated as the unique amino-acid selenocysteine into selenoproteins, which regulate important biologic processes such as redox balance. The results of epidemiologic and clinical investigations are inconclusive regarding the relation of the plasma selenium level to cardiometabolic parameters, and does not support the routine use of selenium supplements to prevent cancer or cardiovascular disease. Variability in the selenium status of the populations studied and lack of standardization of measures of selenium status may account for part of the confusion regarding selenium and cardiometabolic health. Another possibility is that differences in the effects of selenoproteins as opposed to those of low molecular weight selenium compounds derived from in vivo metabolism of selenium, may explain the unusual phenomenon of a similar phenotype induced by both selenium deficiency and excess in experimental models, as well as offer a plausible explanation for the lack of consistency in clinical studies. The epidemiologic, clinical, and experimental evidence, though inconclusive in terms of the precise relation of selenium to cardiometabolic health, is however, very intriguing in terms of the urgent need for further mechanistic research to enable the clinical use of this potent micronutrient.