Circuit Mechanisms of a Retinal Ganglion Cell with Stimulus-Dependent Response Latency and Activation Beyond Its Dendrites.
Circuit Mechanisms of a Retinal Ganglion Cell with Stimulus-Dependent Response Latency and Activation Beyond Its Dendrites.
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DOI：
10.1016/j.cub.2016.12.033
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发表时间：
2017-02-20
期刊：
影响因子：
--
通讯作者：
Schwartz GW
中科院分区：
文献类型：
--
作者：
Mani A;Schwartz GW
几十年来，中心-周围拮抗一直被用作描述视网膜神经节细胞(RGC)感受野的典型模型。我们描述了一种新发现的小鼠RGC类型，称为OND(OND)RGC，其感受野特性偏离了中心-周围组织。OND RGC对光刺激具有异常长的潜伏期，随着视觉刺激大小的增加，OND RGC反应更早。此外，OND RGC受到远远超出其树突的光线的激发。我们揭开了这些现象背后的电路机制的细节，揭示了抑制在控制时间和空间感受场属性中的新角色。OND RGC的非规范感受场特性--长时间和大空间尺度的整合--表明，与典型的RGC不同，它可能编码视觉场景的缓慢变化的全局特性。
Center-surround antagonism has been used as the canonical model to describe receptive fields of retinal ganglion cells (RGCs) for decades. We describe a newly identified RGC type in mouse, called the ON delayed (OND) RGC, with receptive field properties that deviate from center-surround organization. Responding with an unusually long latency to light stimulation, OND RGCs respond earlier as the visual stimulus increases in size. Furthermore, OND RGCs are excited by light falling far beyond their dendrites. We unravel details of the circuit mechanisms behind these phenomena, revealing new roles for inhibition in controlling both temporal and spatial receptive field properties. The non-canonical receptive field properties of the OND RGC – integration of long temporal and large spatial scales – suggest that unlike typical RGCs, it may encode a slowly varying, global property of the visual scene.