CD4+8- HELP PREVENTS RAPID DELETION OF CD8+ CELLS AFTER A TRANSIENT-RESPONSE TO ANTIGEN
CD4+8- HELP PREVENTS RAPID DELETION OF CD8+ CELLS AFTER A TRANSIENT-RESPONSE TO ANTIGEN
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DOI：
10.1002/eji.1830230835
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发表时间：
1993-08-01
影响因子：
5.4
通讯作者：
VONBOEHMER, H
中科院分区：
文献类型：
--
作者：
KIRBERG, J;BRUNO, L;VONBOEHMER, H
我们在有或无辅助的情况下，用造血细胞进行抗原刺激后，追踪了具有雄性特异性转基因T细胞受体的成熟CD8 + T细胞的命运。我们的数据显示，成熟的CD8 + T细胞在3周的短暂激活后可被清除，并且辅助（例如以白细胞介素 - 2的形式）可显著延迟这种清除。这些实验对旨在建立T细胞特异性免疫耐受的方案设计具有启示意义。
We have followed the fate of mature CD8+ T cells with a male-specific transgenic T cell receptor after antigenic stimulation with hemopoietic cells in the absence or presence of help. Our data show that mature CD8+ T cells can be deleted after a 3-week period of transient activation and that help, e.g. in the form of interleukin-2, can considerably delay the deletion. These experiments have implications for the design of protocols aiming at the establishment of specific immunological tolerance in T cells.