Facile One-Pot Synthesis of Meteor Hammer-like Au-MnOx Nanozymes with Spiky Surface for NIR-II Light-Enhanced Bacterial Elimination
Facile One-Pot Synthesis of Meteor Hammer-like Au-MnOx Nanozymes with Spiky Surface for NIR-II Light-Enhanced Bacterial Elimination
复制标题
DOI：
10.1021/acs.chemmater.2c01775
复制
发表时间：
2022-11
影响因子：
8.6
通讯作者：
Xiao-Nan Li;Siman Luo;Yu Chen;Yucheng Zuo;Yuexiang Huang;Hong Zhang;Liheng Chen;Jun Feng
中科院分区：
文献类型：
--
作者：
Xiao-Nan Li;Siman Luo;Yu Chen;Yucheng Zuo;Yuexiang Huang;Hong Zhang;Liheng Chen;Jun Feng
受自然生物之间有效的界面相互作用的启发（例如，苍耳和病毒）和它们的生物宿主，我们开发了一种新型的金锰氧化物纳米颗粒（Au-MnOx）纳米酶，其具有用于NIR-II光诱导的协同抗菌治疗的尖刺表面。Au-MnO具有良好的光热性能和类过氧化物酶活性，可在低浓度的近红外-Ⅱ辐照下实现光热/化学动力学联合治疗。特别值得一提的是，纳米复合抗菌平台的表面具有很强的细菌粘附性，并通过与细菌的有效相互作用，促进了后续的协同PTT/CDT反应。coli，革兰氏阴性）和金黄色葡萄球菌（S.金黄色葡萄球菌，革兰氏阳性）。在混合细菌感染的大鼠伤口模型中，可获得良好的细胞相容性和杀菌效果。本研究提出了一种简便的一锅法，建立了设计良好的Au-MnOx纳米酶与尖刺表面的NIR-II光增强的细菌消除。流星锤状金锰氧化物在构建新型抗菌治疗系统以解决抗生素过度使用方面具有巨大潜力。
Inspired by the effective interfacial interactions between natural creatures (e.g., cockleburs and viruses) and their bio-hosts, we developed a novel gold-manganese oxide nanoparticle (Au-MnOx) nanoenzyme with a spiky surface for NIR-II light-induced synergistic antibacterial therapy. Au-MnOxwith favorable photothermal performance and peroxidase-like activity could achieve combined photothermal therapy (PTT)/chemodynamic therapy (CDT) under NIR-II irradiation with a low concentration. Of special note, the spiky surface endows Au-MnOxrobust bacterial adhesion, in turn favoring the following synergistic PTT/CDT through effective interaction between Au-MnOxand bacteria.In vitroresults display that our combined antibacterial nanoplatforms possess the broad-spectrum antibacterial ability against bothEscherichia coli(E. coli, Gram-negative) andStaphylococcus aureus(S. aureus, Gram-positive). Moreover, satisfactoryin vivobactericidal efficacy and good cytocompatibility could be obtained in the rat wound model with the mixed bacterial infections. This study puts forward a facile one-pot method to establish the well-designed Au-MnOxnanozymes with a spiky surface for NIR-II light-enhanced bacterial elimination. The meteor hammer-like Au-MnOxholds great potential in construction of a novel antibacterial treatment system to settle the overuse of antibiotics.