Quantum dots-based immunofluorescence technology for the quantitative determination of HER2 expression in breast cancer
Quantum dots-based immunofluorescence technology for the quantitative determination of HER2 expression in breast cancer
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基于量子点的免疫荧光技术定量测定乳腺癌中HER2的表达
DOI：
10.1016/j.biomaterials.2009.02.010
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发表时间：
2009-05-01
期刊：
影响因子：
14
通讯作者：
Li, Yan
中科院分区：
文献类型：
--
作者：
Chen, Chuang;Peng, Jun;Li, Yan
HER2检测对乳腺癌的治疗和预后有重要意义，但目前使用的检测方法存在一些不足。基于量子点的探针为临床上检测HER2提供了一种潜在的重要的新方法。这一潜力在本文中得到了检验。研制了量子点HER2探针试剂盒和量子点图像采集与分析软件，并对94例临床标本进行了分析。与常规免疫组织化学方法相比，该方法为临床乳腺癌的HER2检测提供了一种更准确、更敏感的方法。(C)2009爱思唯尔有限公司。保留所有权利。
HER2 detection is important for breast cancer (BC) treatment and prognosis, but the detection methods currently used have some disadvantages. Quantum dots (QDs)-based probes provide a potentially important new method for HER2 detection in clinical practice. This potential is examined in this paper. A QDs HER2 probe kit and QDs image acquisition and analysis software were developed and applied to 94 clinical samples of BC. Compared to conventional immunohistochemistry techniques, this method provided a superior accurate and sensitive method for the detection of HER2 in clinical breast cancer diagnosis. (C) 2009 Elsevier Ltd. All rights reserved.