Possible relationship between neurocysticercosis and hematological malignancies
Possible relationship between neurocysticercosis and hematological malignancies
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DOI：
10.1016/s0188-0128(98)00027-x
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发表时间：
1999-03-01
影响因子：
7.7
通讯作者：
Ostrosky-Wegman, P
中科院分区：
文献类型：
--
作者：
Herrera, LA;Benita-Bordes, A;Ostrosky-Wegman, P
背景先前的研究表明，在患有囊虫病的动物和人类的淋巴细胞中，染色体异常的频率增加。一些报告表明癌症和囊虫病之间存在联系。本研究的目的是探讨脑囊虫病和cancer.Methods之间的可能关联，我们设计了一个死亡率的研究，从尸检文件的病理部门在墨西哥总医院。共审查了1 271份尸检档案。所有在尸检过程中发现恶性肿瘤的文件都被选为病例。没有发现恶性疾病的尸检被用作对照。任何恶性肿瘤患者的脑囊虫病的频率和controls.Results之间的比值比，脑囊虫病是更常见的恶性血液病（MHD）的情况下，比对照组（p = 0.01）。这种关联的比值比为3.54，95%可信区间为1.17- 9.79。大多数人类癌症是由多种因素的相互作用引起的，包括外源性物质和内源性成分，因此，虽然很难证明脑囊虫病是恶性血液病（MHD）的致病因子，但在囊虫病仍然是公共卫生问题的国家，应将其视为癌症诱导的潜在风险因素。(C)1999 IMSS，由Elsevier Science Inc.出版。
Background. Previous studies have shown an increased frequency of chromosomal abnormalities in lymphocytes from animals and humans with cysticercosis. Some reports have suggested an association between cancer and cysticercosis. The aim of this study was to investigate the possible association between neurocysticercosis and cancer.Methods, We designed a mortality rate study from the autopsy files of the Department of Pathology at the General Hospital of Mexico. A total of 1,271 autopsy files were reviewed. All files in which a malignant neoplasia was found during autopsy were selected as cases. Autopsies in which no malignant disease was found were used as controls. The odds ratio was determined between the frequency of neurocysticercosis in patients with any malignant neoplasia and that of the controls.Results, Neurocysticercosis was more frequent in cases with malignant hematological diseases (MHD) than in controls (p = 0.01). The odds ratio for this association was 3.54, with 95% confidence interval from 1.17-9.79.Conclusions. Most human cancers arise from the interaction of a multiplicity of factors, including xenobiotics and endogenous constituents, Therefore, while it will be difficult to demonstrate that neurocysticercosis is a causal agent of malignant hematological diseases (MHD), it should be considered as a potential risk factor for cancer induction in countries where cysticercosis remains a public health problem. (C) 1999 IMSS, Published by Elsevier Science Inc.