Time-reversed ultrasonically encoded optical focusing through highly scattering ex vivo human cataractous lenses.
Time-reversed ultrasonically encoded optical focusing through highly scattering ex vivo human cataractous lenses.
复制标题
DOI：
10.1117/1.jbo.23.1.010501
复制
发表时间：
2018-01
影响因子：
3.5
通讯作者：
Wang LV
中科院分区：
文献类型：
--
作者：
Liu Y;Shen Y;Ruan H;Brodie FL;Wong TTW;Yang C;Wang LV
婴儿视觉系统的正常发育依赖于投射到视网膜上的清晰图像，这可能被先天性白内障引起的透镜混浊所破坏。这种破坏，如果在生命早期不纠正，会导致弱视（即使在白内障摘除后视力也会永久下降）。医生能够通过在出生后的前几周内摘除白内障来预防弱视，但这种手术有一系列并发症的风险，这些并发症同样会导致视力残疾。在这里，我们研究了通过高散射性白内障晶状体非侵入性地聚焦光以刺激视网膜从而预防弱视的可行性。这种方法可以延迟白内障透镜摘除手术，从而大大降低早期手术并发症的风险。采用波前成形技术，称为时间反演超声编码的光学聚焦反射模式，我们通过一个高度散射的离体成人白内障透镜聚焦532 nm的光。这项工作表明了波前整形技术的潜在临床应用。
Normal development of the visual system in infants relies on clear images being projected onto the retina, which can be disrupted by lens opacity caused by congenital cataract. This disruption, if uncorrected in early life, results in amblyopia (permanently decreased vision even after removal of the cataract). Doctors are able to prevent amblyopia by removing the cataract during the first several weeks of life, but this surgery risks a host of complications, which can be equally visually disabling. Here, we investigated the feasibility of focusing light noninvasively through highly scattering cataractous lenses to stimulate the retina, thereby preventing amblyopia. This approach would allow the cataractous lens removal surgery to be delayed and hence greatly reduce the risk of complications from early surgery. Employing a wavefront shaping technique named time-reversed ultrasonically encoded optical focusing in reflection mode, we focused 532-nm light through a highly scattering ex vivo adult human cataractous lens. This work demonstrates a potential clinical application of wavefront shaping techniques.