Dopaminergic contributions to modulatory functions of a dual-transmitter interneuron in Aplysia
Dopaminergic contributions to modulatory functions of a dual-transmitter interneuron in Aplysia
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DOI：
10.1016/j.neulet.2003.12.058
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发表时间：
2004-03-18
影响因子：
2.5
通讯作者：
Weiss, KR
中科院分区：
文献类型：
--
作者：
Due, MR;Jing, J;Weiss, KR
大腹虫的摄食中枢模式产生器产生的运动程序可能在摄食或摄食的程度上有所不同。许多产生模式的中间神经元在形成运动程序中起着重要作用。其中一个中间神经元B65很不寻常，因为它含有两种经典的神经递质，多巴胺和γ -氨基丁酸。在这里，我们研究其中一种递质多巴胺的作用，使用药理学和电生理手段的结合。我们发现B65使用多巴胺在几个跟随神经元中引发快速突触电位。此外，我们证明多巴胺拮抗剂舒必利模拟双侧B65超极化对排血运动程序的影响。因此，我们的数据表明，多巴胺能传递有助于增加运动程序的消极程度，并减少延长期的持续时间。2003爱思唯尔爱尔兰有限公司版权所有。
The feeding central pattern generator of Aplysia produces motor programs that can differ in the degree to which they are ingestive or egestive. A number of pattern-generating interneurons that play an important role in shaping motor programs have been identified. One of these interneurons, B65, is unusual in that it contains two classical neurotransmitters, dopamine and gamma-aminobutyric acid. Here, we study the role of one of these transmitters, dopamine, using a combination of pharmacological and electrophysiological means. We show that B65 uses dopamine to elicit fast synaptic potentials in several follower neurons. Furthermore, we demonstrate that the dopamine antagonist sulpiride mimics the effect of bilateral B65 hyperpolarization on egestive motor programs. Thus our data suggest that dopaminergic transmission serves to increase the degree of egestiveness of motor programs, and decrease the duration of the protraction phase. (C) 2003 Elsevier Ireland Ltd. All rights reserved.