Spatial overlap of rubrospinal and corticospinal terminals with input to the inferior olive.
Spatial overlap of rubrospinal and corticospinal terminals with input to the inferior olive.
复制标题
红核脊髓和皮质脊髓末端的空间重叠与下橄榄的输入。
DOI：
10.1016/1053-8119(92)90005-8
复制
发表时间：
1992
期刊：
影响因子：
5.7
通讯作者：
Houk,JC
中科院分区：
文献类型：
--
作者：
McCurdy,ML;Gibson,AR;Houk,JC
在背侧副橄榄的细胞的体感反应被抑制后的大细胞红核的刺激。由于猫的大细胞红核不直接投射到背侧副橄榄，本实验旨在确定间接途径，可能介导抑制橄榄反应。麦胚凝集素-辣根过氧化物酶被用来比较的位置大细胞红核终端的位置提供输入的头侧背侧副橄榄的细胞。投射到前肢喙背侧副橄榄的细胞可以分为两个主要的组：一组包括一列位于腹侧尾侧楔状核延伸到第六层的C1和C2，第二组包括位于腹侧喙侧楔状核的较小的细胞。起源于大细胞红核的纤维的终止被发现针对这两组投射到背侧副橄榄的细胞。因此，有可能橄榄细胞的反应性是通过这些终端的影响。刺激感觉运动皮层也被证明可以抑制橄榄核的反应。从感觉运动皮层终止的目标相同的区域的细胞，项目的背侧副橄榄的大细胞红核，和一个类似的，也许是相同的，解剖基板可能有助于调节橄榄的敏感性由两个下降系统。
Somatosensory responses of cells in the dorsal accessory olive are suppressed following stimulation of the magnocellular red nucleus. Since the magnocellular red nucleus of the cat does not project directly to the dorsal accessory olive, the present experiments were designed to identify indirect pathways that might mediate suppression of olivary responsiveness. Wheat germ agglutinin-horseradish peroxidase was used to compare the location of magnocellular red nucleus terminals with the locations of cells providing input to the rostral dorsal accessory olive. Cells projecting to forelimb rostral dorsal accessory olive can be divided into two main groups: one group comprises a column of large cells located in the ventral caudal cuneate nucleus extending into lamina VI of C1 and C2, and a second group comprises smaller cells located in the ventral rostral cuneate nucleus. Terminations of fibers originating in the magnocellular red nucleus were found to target both groups of cells projecting to the dorsal accessory olive. Therefore, it is possible that the responsiveness of olivary cells is influenced via these terminations. Stimulation of sensorimotor cortex has also been shown to inhibit olivary responsiveness. Terminations from sensorimotor cortex target the same regions of cells that project to the dorsal accessory olive as those of the magnocellular red nucleus, and a similar, perhaps identical, anatomical substrate may serve to modulate olivary sensitivity by the two descending systems.