Validation of finite element predictions of cartilage contact pressure in the human hip joint.
Validation of finite element predictions of cartilage contact pressure in the human hip joint.
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DOI：
10.1115/1.2953472
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发表时间：
2008-10
期刊：
影响因子：
--
通讯作者：
Weiss JA
中科院分区：
文献类型：
--
作者：
Anderson AE;Ellis BJ;Maas SA;Peters CL;Weiss JA
预测髋关节接触应力的方法可以更好地了解正常和病理关节的载荷分布。本研究的目的是开发和验证一个三维有限元（FE）模型，用于预测软骨接触应力在人类髋关节使用特定的几何形状从计算机断层扫描图像数据，并评估模型预测的敏感性边界条件，软骨几何形状和软骨材料的属性。基于体内数据的载荷施加到尸体髋关节上，以模拟行走、下楼梯和爬楼梯。使用压敏膜测量接触压力和面积。对CT图像数据进行分割和离散，得到骨和软骨的有限元网格。有限元边界和加载条件模拟实验测试。公平良好的定性对应FE预测和实验测量模拟行走和下楼梯，而获得良好的协议爬楼梯。实验峰值压力、平均压力和接触面积分别为10.0 MPa（膜检测极限）、4.4-5.0 MPa和321.9-425.1 mm 2，而FE预测峰值压力、平均压力和接触面积分别为10.8-12.7 MPa、5.1-6.2 MPa和304.2-366.1 mm 2。未对准误差（确定为FE结果对准前后均方根误差的差异）小于10%。幅度误差，确定为校准后的残余误差，约为30%，但降低到10-15%时，最高压力的区域进行了比较。软骨剪切模量、体积模量或厚度的改变导致峰值压力变化±25%，而平均压力和接触面积的变化较小（±10%）。当骨盆和股骨近端表现为刚性时，变化较大，但影响取决于特定的载荷情况。总的来说，特定主题的FE预测相比有利的压力膜测量，并在良好的协议与发表的实验数据。经验证的建模框架为开发患者特定的FE模型提供了基础，以研究正常和病理性髋关节的力学。
Methods to predict contact stresses in the hip can provide an improved understanding of load distribution in the normal and pathologic joint. The objectives of this study were to develop and validate a three-dimensional finite element (FE) model for predicting cartilage contact stresses in the human hip using subject-specific geometry from computed tomography image data, and to assess the sensitivity of model predictions to boundary conditions, cartilage geometry, and cartilage material properties. Loads based on in vivo data were applied to a cadaveric hip joint to simulate walking, descending stairs and stair-climbing. Contact pressures and areas were measured using pressure sensitive film. CT image data were segmented and discretized into FE meshes of bone and cartilage. FE boundary and loading conditions mimicked the experimental testing. Fair to good qualitative correspondence was obtained between FE predictions and experimental measurements for simulated walking and descending stairs, while excellent agreement was obtained for stair-climbing. Experimental peak pressures, average pressures, and contact areas were 10.0 MPa (limit of film detection), 4.4-5.0 MPa and 321.9-425.1 mm2, respectively, while FE predicted peak pressures, average pressures and contact areas were 10.8-12.7 MPa, 5.1-6.2 MPa and 304.2-366.1 mm2, respectively. Misalignment errors, determined as the difference in root mean squared error before and after alignment of FE results, were less than 10%. Magnitude errors, determined as the residual error following alignment, were approximately 30% but decreased to 10-15% when the regions of highest pressure were compared. Alterations to the cartilage shear modulus, bulk modulus, or thickness resulted in ±25% change in peak pressures, while changes in average pressures and contact areas were minor (±10%). When the pelvis and proximal femur were represented as rigid, there were large changes, but the effect depended on the particular loading scenario. Overall, the subject-specific FE predictions compared favorably with pressure film measurements and were in good agreement with published experimental data. The validated modeling framework provides a foundation for development of patient-specific FE models to investigate the mechanics of normal and pathological hips.
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影响因子：
2.4
作者：
Genda, E;Iwasaki, N;Chao, EYS
通讯作者：
Chao, EYS
DOI：
10.1115/1.2720918
发表时间：
2007-06-01
影响因子：
1.7
作者：
Ateshian, Gerard A.;Ellis, Benjamin J.;Weiss, Jeffrey A.
通讯作者：
Weiss, Jeffrey A.
影响因子：
2.4
作者：
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通讯作者：
Duda, GN
影响因子：
19.7
作者：
Anderson, Andrew E.;Ellis, Benjamin J.;Weiss, Jeffrey A.
通讯作者：
Weiss, Jeffrey A.
DOI：
10.1097/01.blo.0000132633.38338.8b
发表时间：
2004-06-01
影响因子：
4.2
作者：
Brown, TD;Rudert, MJ;Grosland, NM
通讯作者：
Grosland, NM