Consensus conference definitions for sepsis, septic shock, acute lung injury, and acute respiratory distress syndrome: Time for a reevaluation
Consensus conference definitions for sepsis, septic shock, acute lung injury, and acute respiratory distress syndrome: Time for a reevaluation
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DOI：
10.1097/00003246-200001000-00039
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发表时间：
2000-01-01
影响因子：
8.8
通讯作者：
Repine, JE
中科院分区：
文献类型：
--
作者：
Abraham, E;Matthay, MA;Repine, JE
脓毒症、脓毒性休克、急性肺损伤（ALI）和急性呼吸窘迫综合征（ARDS）的定义由共识会议制定，目的是实现术语标准化和提高临床研究中患者人群的同质性。虽然这样的定义在流行病学调查中是有用的，但共识会议规定的标准是宽泛的，并且不足以解决导致临床综合征的异质性机制的问题。一个重要的挑战是从目前定义的临床综合征进展到通过特异性免疫或生化途径的改变描绘的更特异性实体。这样的机制定义将提供更同质的患者组，这些患者可以在其临床过程的早期阶段被识别。这种方法鼓励集中调查的途径，导致器官系统功能障碍和死亡，也提供了一个有效的框架，用于发展新的治疗方法，在危重病人。
Definitions for sepsis, septic shock, acute lung injury (ALI), and acute respiratory distress syndrome (ARDS) were developed by consensus conferences with the goal of achieving standardization of terminology and improved homogeneity of patient populations in clinical studies. Although such definitions have been useful in epidemiologic investigations, the criteria specified by the consensus conferences are broad and insufficiently specific to address the problem of heterogeneous mechanisms leading to clinical syndromes, An important challenge is to progress from clinical syndromes, as presently defined, to more specific entities that are delineated by alterations in specific immunologic or biochemical pathways. Such mechanistic definitions will provide more homogeneous groups of patients who can be identified at early stages of their clinical course. This approach encourages focused investigation of pathways leading to organ system dysfunction and death and, also, provides an efficient framework for the development of new therapies useful in critically ill patients.