Programmed cell death during neuronal development: the sympathetic neuron model.
Programmed cell death during neuronal development: the sympathetic neuron model.
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DOI：
10.1038/cdd.2014.47
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发表时间：
2014-07
影响因子：
12.4
通讯作者：
中科院分区：
文献类型：
--
作者：
上级颈神经节的交感神经元的发育是神经元凋亡的最佳研究模型之一。这些细胞需要神经生长因子（NGF）的生存时间，他们支配他们的最终目标组织在胚胎晚期和出生后早期的发展。在缺乏NGF的情况下，发育中的交感神经元以转录依赖的方式通过凋亡而死亡。交感神经元凋亡的分子研究始于20世纪80年代。我们现在知道，在体外培养的交感神经元中，神经生长因子的退出激活线粒体（内在）凋亡途径，并且半胱天冬酶、Bcl-2（B细胞CLL/淋巴瘤2）家族蛋白和XIAP（X连锁凋亡抑制蛋白）的作用已被广泛研究。重要的是，也已经了解了相当多的细胞内信号通路和转录因子，调节交感神经元中的程序性细胞死亡。在这篇文章中，我们回顾了过去几年发表的关键论文，涵盖了交感神经元凋亡调控的各个方面，特别是集中在信号通路和转录因子如何调节细胞死亡程序。我们做了一些比较与其他模型的神经元凋亡，并描述了该领域未来可能的发展方向。
Developing sympathetic neurons of the superior cervical ganglion are one of the best studied models of neuronal apoptosis. These cells require nerve growth factor (NGF) for survival at the time that they innervate their final target tissues during late embryonic and early postnatal development. In the absence of NGF, developing sympathetic neurons die by apoptosis in a transcription-dependent manner. Molecular studies of sympathetic neuron apoptosis began in the 1980s. We now know that NGF withdrawal activates the mitochondrial (intrinsic) pathway of apoptosis in sympathetic neurons cultured in vitro, and the roles of caspases, Bcl-2 (B-cell CLL/lymphoma 2) family proteins and XIAP (X-linked inhibitor of apoptosis protein) have been extensively studied. Importantly, a considerable amount has also been learned about the intracellular signalling pathways and transcription factors that regulate programmed cell death in sympathetic neurons. In this article, we review the key papers published in the past few years, covering all aspects of apoptosis regulation in sympathetic neurons and focusing, in particular, on how signalling pathways and transcription factors regulate the cell death programme. We make some comparisons with other models of neuronal apoptosis and describe possible future directions for the field.
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影响因子：
16.2
作者：
Atwal, JK;Massie, B;Kaplan, DR
通讯作者：
Kaplan, DR
影响因子：
5.3
作者：
Bishop, Tammie;Gallagher, Denis;Ratcliffe, Peter J.
通讯作者：
Ratcliffe, Peter J.
影响因子：
16.2
作者：
Deshmukh, M;Johnson, EM
通讯作者：
Johnson, EM
影响因子：
7.8
作者：
Besirli, CG;Wagner, EF;Johnson, EM
通讯作者：
Johnson, EM
DOI：
10.1083/jcb.123.5.1207
发表时间：
1993-12
期刊：
The Journal of cell biology
影响因子：
--
作者：
Deckwerth TL;Johnson EM Jr
通讯作者：
Johnson EM Jr