Erythropoietin exerts neuroprotection in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated C57/BL mice via increasing nitric oxide production
Erythropoietin exerts neuroprotection in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated C57/BL mice via increasing nitric oxide production
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DOI：
10.1016/s0304-3940(00)01716-x
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发表时间：
2001-02-02
影响因子：
2.5
通讯作者：
Gure, A
中科院分区：
文献类型：
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作者：
Genc, S;Kuralay, F;Gure, A
促红细胞生成素（EPO），由肾脏和胎儿肝脏产生，是一种在缺氧条件下刺激红细胞生成的肾上腺素激素。已经表明EPO在中枢神经系统中产生，并且其受体在神经元上表达。由于EPO在体外和体内对脑损伤具有神经保护作用，我们在1-甲基-4-苯基-1，2，3，6-四氢吡啶（MPTP）诱导的帕金森病动物模型中研究了EPO治疗对动物运动活动、黑质多巴胺能神经元存活以及黑质和纹状体硝酸盐水平的影响。我们的研究结果表明，EPO通过增加一氧化氮的产生，对MPTP诱导的帕金森病小鼠模型的神经毒性具有保护和治疗作用。(C)2001爱思唯尔科学爱尔兰有限公司保留所有权利。
Erythropoietin (EPO), produced by the kidney and fetal liver, is a cytokine-hormone that stimulates erythropoiesis under hypoxic conditions. It has been shown that EPO is produced in the central nervous system and its receptor is expressed on neurons. Since EPO has neuroprotective effects in vitro and in vivo against brain injury, we investigated the effect of EPO treatment on locomotor activities of animals, survival of nigral dopaminergic neurons and nitrate levels in substantia nigra and striatum in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced animal model of Parkinsonism in C57/BL mice. Our findings suggest that EPO has protective and treating effect in MPTP-induced neurotoxicity in this mouse model of Parkinson's Disease via increasing nitric oxide production. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.