MICRODIALYSIS MEASUREMENT OF INVIVO NEUROPEPTIDE RELEASE
MICRODIALYSIS MEASUREMENT OF INVIVO NEUROPEPTIDE RELEASE
复制标题
DOI：
10.1016/0165-0270(90)90040-m
复制
发表时间：
1990-09-01
影响因子：
3
通讯作者：
KENDRICK, KM
中科院分区：
文献类型：
--
作者：
KENDRICK, KM
讨论了微透析取样技术在体内测定神经肽释放量中的应用。不同的微透析膜的体外回收率描述了各种神经肽（范围从400到4500 MW），以及他们的动态电位测量外部浓度变化。体内实验说明了使用该技术来测量从清醒的羊的大脑中释放的催产素和脑啡肽，以及麻醉大鼠血液中的加压素。
The application of the microdialysis sampling technique for in vivo measurement of neuropeptide release is discussed. In vitro recoveries of different microdialysis membranes are described for a variety of neuropeptides (ranging from 400 to 4500 MW) as well as their dynamic potential for measuring external concentration changes. In vivo experiments illustrating the use of the technique for measuring release of oxytocin and met-enkephalin from the brain of the conscious sheep, and vasopressin in the blood of the anaesthetised rat are described.