The effect of ultrasound-guided percutaneous ozone injection around cervical dorsal root ganglion in zoster-associated pain: a retrospective study.
The effect of ultrasound-guided percutaneous ozone injection around cervical dorsal root ganglion in zoster-associated pain: a retrospective study.
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DOI：
10.2147/jpr.s163340
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发表时间：
2018
影响因子：
2.7
通讯作者：
Williams JP
中科院分区：
文献类型：
--
作者：
Lin SY;Zhang SZ;An JX;Qian XY;Gao XY;Wang Y;Zhao WX;Eastwood D;Cope DK;Williams JP
本研究旨在评价超声引导下经皮穿刺臭氧注射治疗带状疱疹相关性疼痛（ZAP）患者颈背根神经节周围的有效性。回顾性比较研究。这项研究是在一所大学医院的疼痛中心进行的。从2016年6月至2017年7月，共有30例ZAP患者在损伤神经水平（C2-C8）的颈背根神经节（DRG）周围接受了超声引导下经皮臭氧注射治疗。将浓度为30 µg/mL的3 mL臭氧-氧气混合物注入DRG周围区域。根据病程分为A组（≤ 3个月）和B组（>3个月）。根据视觉模拟量表评估疼痛严重程度，并通过超声评估影像学变化。在1至3个月的随访期间，评价患者疼痛和神经功能的改善。数据显示，臭氧注射减少了ZAP患者的疼痛。但A组的成功率高于B组。注射后，两组的von Frey数据均显示降低，但组间无显著差异。单因素Logistic回归分析和多因素Logistic回归分析显示糖尿病史对治疗效果有显著影响。经皮臭氧注射周围的DRG可能是一个有用的方法治疗耐药的情况下，ZAP在颈部水平。机构审查委员会（IRB）批准编号：HK 2017 -1130。
This study was to evaluate the effectiveness of ultrasound-guided percutaneous ozone injections around the cervical dorsal root ganglions of zoster-associated pain (ZAP) patients. Retrospective comparative study. The study was conducted at a pain center of a university hospital. From June 2016 to July 2017, a total number of 30 patients with ZAP were treated with ultrasound-guided percutaneous ozone injection around the cervical dorsal root ganglion (DRG) at the injured nerve level (C2-C8). A volume of 3 mL ozone-oxygen mixture at a concentration of 30 µg/mL was injected into the area around the DRG. Patients were divided into two groups according to their disease duration: group A (at or <3 months) and group B (>3 months). The pain severity was assessed according to a visual analog scale, and imaging changes were evaluated by ultrasound. Patient improvements in pain and neurologic function were evaluated during a follow-up period from 1 to 3 months. The data showed that ozone injections reduced pain in patients with ZAP. However, the success rate of group A was higher than group B. After the injection, the von Frey data demonstrated decreases in both groups, but, there were no significant differences between the groups. Moreover, univariate logistic regression analysis and multivariate regression analysis showed a history of diabetes mellitus had a significant effect on the treatment results. Percutaneous ozone injection around the DRG might be a useful method for treatment-resistant cases of ZAP at the cervical level. Institutional Review Board (IRB) approval number: HK2017-1130.