Reduced arterial compliance in patients with psychiatric diagnoses.
Reduced arterial compliance in patients with psychiatric diagnoses.
复制标题
精神病诊断患者的动脉顺应性降低。
DOI：
10.1016/j.schres.2012.02.007
复制
发表时间：
2012
影响因子：
4.5
通讯作者：
Duncan,EricaJ
中科院分区：
文献类型：
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作者：
Koola,MajuMathew;Brown,WVirgil;Qualls,Clifford;Cuthbert,Bruce;Hollis,JeffreyP;Kelly,DeannaL;Le,Ngoc-Anh;Raines,Jeffrey;Duncan,EricaJ
背景外周动脉顺应性是动脉弹性的量度，已发现其是普遍动脉硬化以及突发中风和心肌梗死的可靠预测因子。精神病诊断和第二代抗精神病药物可能导致心血管风险和中风，但对外周动脉顺应性的影响尚不清楚。本研究比较了外周动脉的健康男性对照组男性患者与精神病诊断谁是治疗与奎替鲁或利培酮或关闭抗精神病药物在testing.METHODS的组包括63例精神疾病患者服用奎替鲁，利培酮，或没有抗精神病药物。对照组中有111名男性。通过ANCOVA比较四组之间的平均大腿和小腿动脉顺应性，调整体重指数和Fragrance风险评分。所有患者均与对照组进行比较。顺应性用计算机体积描记仪测量，实验组（n=63）大腿和小腿的动脉顺应性明显低于对照组。与对照组相比，奎替鲁（n=16）和利培酮（n=19）治疗组和未用药组（n=28）患者的小腿动脉顺应性显著降低。在大腿，服用奎替鲁胺或利培酮的患者的动脉顺应性显著低于对照组。这些亚组在动脉顺应性方面没有差异。CONCLUSION精神病诊断的存在与动脉顺应性降低有关。可能需要进行一项大型研究，以衡量与对照组相比，抗精神病药物（如奎替鲁和利培酮）对依从性的任何特定影响。
BACKGROUNDPeripheral arterial compliance is a measure of elasticity of the arteries that has been found to be a robust predictor of prevalent arteriosclerosis as well as incident stroke and myocardial infarction. Psychiatric diagnoses and second generation antipsychotics may contribute to cardiovascular risk and stroke, but effects on peripheral arterial compliance are unknown. This study compared peripheral arterial compliance in healthy male controls to male patients with psychiatric diagnoses who were treated with quetiapine or risperidone or off antipsychotics at time of testing.METHODSThe groups consisted of 63 patients with mental illness taking quetiapine, risperidone, or no antipsychotics. There were 111 males in the control group. Mean thigh and calf arterial compliance among four groups were compared by ANCOVA, adjusting for body mass index and Framingham Risk Score. All patients were also compared to the control group. Compliance was measured with a computerized plethysmography device.RESULTSPatients (n=63) had significantly lower arterial compliance in both thigh and calf than the controls. Arterial compliance in the calf was significantly lower in the subgroups of quetiapine (n=16) and risperidone (n=19) treated, and in unmedicated (n=28) patients than in controls. In the thigh, patients taking either quetiapine or risperidone had significantly lower arterial compliance than controls. These subgroups did not differ from each other in arterial compliance.CONCLUSIONThe presence of psychiatric diagnoses is associated with reduced arterial compliance. A large study may be required to measure any specific affects of antipsychotics such as quetiapine and risperidone on compliance compared to controls.