Insulin resistance and white adipose tissue inflammation are uncoupled in energetically challenged Fsp27-deficient mice.
Insulin resistance and white adipose tissue inflammation are uncoupled in energetically challenged Fsp27-deficient mice.
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在受到能量挑战的 Fsp27 缺陷小鼠中，胰岛素抵抗和白色脂肪组织炎症是不相关的
DOI：
10.1038/ncomms6949
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发表时间：
2015-01-07
影响因子：
16.6
通讯作者：
Li, Peng
中科院分区：
文献类型：
--
作者：
Zhou, Linkang;Park, Shi-Young;Xu, Li;Xia, Xiayu;Ye, Jing;Su, Lu;Jeong, Kyeong-Hoon;Hur, Jang Ho;Oh, Hyunhee;Tamori, Yoshikazu;Zingaretti, Cristina M.;Cinti, Saverio;Argente, Jesus;Yu, Miao;Wu, Lizhen;Ju, Shenghong;Guan, Feifei;Yang, Hongyuan;Choi, Cheol Soo;Savage, David B.;Li, Peng
FSP27是一种脂滴相关蛋白，几乎只在脂肪细胞中表达，促进单眼脂滴的形成。在小鼠中，Fsp27缺乏症与基础脂解增加、白色脂肪“褐变”和健康的代谢特征有关，而先天性CIDEC缺乏症患者表现出不利的脂肪营养不良表型。在这里，我们协调了这些数据，表明通过将Fsp27基因缺失的小鼠与ob/ob小鼠或无BAT小鼠杂交，或给它们喂食高脂肪食物，将它们暴露在大量的能量应激下，导致肝脏脂肪变性和胰岛素抵抗。我们还观察到，在所有三个模型中，脂肪炎症显著减少，脂联素水平上升。这似乎反映了炎性小体的激活减少，脂肪细胞死亡减少。这些发现突显了Fsp27在促进脂肪细胞最佳能量储存方面的重要性，并代表了脂肪炎症和肝脏胰岛素抵抗分离的罕见例子。Fsp27介导小鼠脂肪组织中脂滴的“融合”。在这里，作者研究了三种不同的能量超负荷小鼠模型中Fsp27缺失的生理后果，并观察了肝脏脂肪变性和胰岛素抵抗，但减轻了脂肪组织的炎症。
Fsp27 is a lipid droplet-associated protein almost exclusively expressed in adipocytes where it facilitates unilocular lipid droplet formation. In mice, Fsp27 deficiency is associated with increased basal lipolysis, ‘browning’ of white fat and a healthy metabolic profile, whereas a patient with congenital CIDEC deficiency manifested an adverse lipodystrophic phenotype. Here we reconcile these data by showing that exposing Fsp27-null mice to a substantial energetic stress by crossing them with ob/ob mice or BATless mice, or feeding them a high-fat diet, results in hepatic steatosis and insulin resistance. We also observe a striking reduction in adipose inflammation and increase in adiponectin levels in all three models. This appears to reflect reduced activation of the inflammasome and less adipocyte death. These findings highlight the importance of Fsp27 in facilitating optimal energy storage in adipocytes and represent a rare example where adipose inflammation and hepatic insulin resistance are disassociated. Fsp27 mediates ‘fusion’ of lipid droplets in mouse adipose tissue. Here, the authors investigate the physiological consequences of loss of Fsp27 in three different mouse models of ‘energetic overload’, and observe hepatic steatosis and insulin resistance but reduced adipose tissue inflammation.
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影响因子：
12.3
作者：
Gentleman RC;Carey VJ;Bates DM;Bolstad B;Dettling M;Dudoit S;Ellis B;Gautier L;Ge Y;Gentry J;Hornik K;Hothorn T;Huber W;Iacus S;Irizarry R;Leisch F;Li C;Maechler M;Rossini AJ;Sawitzki G;Smith C;Smyth G;Tierney L;Yang JY;Zhang J
通讯作者：
Zhang J
影响因子：
7.7
作者：
Gray, Sarah L.;Nora, Edoardo Dalla;Vidal-Puig, Antonio
通讯作者：
Vidal-Puig, Antonio
影响因子：
7.7
作者：
Nordström, EA;Rydén, M;Arner, P
通讯作者：
Arner, P
诱导细胞死亡的 DFF45 样效应器 b (Cideb) 存在于胰腺 β 细胞中，并参与棕榈酸酯诱导的 β 细胞凋亡
影响因子：
8
作者：
Li, H.;Song, Y.;Li, Q.
通讯作者：
Li, Q.
影响因子：
64.8
作者：
Perry, Rachel J.;Samuel, Varman T.;Petersen, Kitt F.;Shulman, Gerald I.
通讯作者：
Shulman, Gerald I.