PET/C of the abdomen: optimizing the patient breathing pattern
PET/C of the abdomen: optimizing the patient breathing pattern
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DOI：
10.1007/s00330-002-1548-2
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发表时间：
2003-04-01
影响因子：
5.9
通讯作者：
von Schulthess, GK
中科院分区：
文献类型：
--
作者：
Goerres, GW;Burger, C;von Schulthess, GK
本研究的目的是评估呼吸位置，该位置最适合腹部 CT 图像的共同配准，以及新的组合 PET/CT 系统中相应的正电子发射断层扫描 (PET) 扫描。 10 名患者（5 名男性，5 名女性；年龄 57.7 +/- 15.3 岁，年龄范围 34-80 岁）在组合 PET/CT 扫描仪（Discovery LS，GE Medical Systems，密尔沃基，威斯康星州）上接受了肿瘤分期成像。 PET 发射图像是在正常浅呼吸期间采集的，在 CT 扫描期间，患者执行四种不同的呼吸任务：自由呼吸 (FB)；最大灵感（MaxInsp）；最大过期时间（MaxExp）；和正常到期 (NormExp)。 NormExp被定义为患者首先吸气，然后呼气而不用力呼气，然后在此位置屏住呼吸时所达到的呼吸水平。以骶骨岬为参考点，由两名独立观察者测量 PET 和 CT 图像中该点到腹部器官的距离，测量脾、肝、左右肾和膀胱的运动。使用带有 Bonferroni 校正的 Wilcoxon 符号秩检验对 CT 扫描和 PET 扫描之间的测量距离进行统计比较。重复测量方差分析用于评估观察者内和观察者间的一致性。 NormExp 和 FB 之间没有显着差异，表明两种呼吸方案都适合腹部研究的 PET/CT 图像联合配准。相比之下，MaxExp 和 MaxInsp 协议就不适合。 NormExp 和 FB 呼吸方案均适合腹部 PET/CT 研究的联合注册。在大多数患者中，腹部器官的不匹配将低于最终联合配准 PET/CT 图像的分辨率。
The aim of this study was to evaluate the respiration position, which is optimal for co-registration of abdominal CT images, and the corresponding positron emission tomography (PET) scan in a new combined PET/CT system. Ten patients (5 men, 5 women; age 57.7 +/- 15.3 years, age range 34-80 years) underwent imaging for tumor staging on a combined PET/CT scanner (Discovery LS, GE Medical Systems, Milwaukee, Wis.). The PET emission images were acquired during normal shallow breathing and during CT scanning the patients performed four different breathing tasks: free breathing (FB); maximum inspiration (MaxInsp); maximum expiration (MaxExp); and normal expiration (NormExp). NormExp was defined as the respiratory level that was reached when the patient first inhaled and then exhaled without forcing expiration, and then held the breath in this position. Movements of the spleen, liver, left and right kidney, and the bladder were measured by using the promontory of the sacrum as a reference point and measuring the distance from this point to the abdominal organs in the PET and CT images by two independent observers. Statistical comparison of the measured distances between the CT scans and the PET scan were made using a Wilcoxon signed-rank test with Bonferroni correction. Repeated measures analysis of variance served for the assessment of intraobserver and interobserver agreement. There was no significant difference between NormExp and FB indicating that both respiration protocols are suitable for PET/CT image co-registration of abdominal studies. In contrast, the MaxExp and MaxInsp protocol are not suitable. The NormExp and FB respiration protocol are both suitable for the co-registration of abdominal PET/CT studies. In most patients the mismatch of abdominal organs will be lower than the resolution of the final co-registered PET/ CT image.