Atypical lipoteichoic acids of gram-positive bacteria
Atypical lipoteichoic acids of gram-positive bacteria
复制标题
革兰氏阳性菌的非典型脂磷壁酸
作者：
I. Sutcliffe;N. Shaw
脂磷壁酸（LTA）通常被称为革兰氏阳性菌的膜相关聚合物特征，正如脂多糖被认为在革兰氏阴性菌中普遍存在一样。通常，常规LTA是共价连接至膜锚的16至40个磷酸二酯连接的甘油磷酸残基的线性聚合物，所述膜锚通常类似于在细胞膜的游离脂质中发现的糖脂或糖磷脂。甘油磷酸残基的C-2位可以是NAD-丙氨酰化和/或糖基化的。这些常规LTA的结构、功能和生物合成已被广泛综述（17，68）。然而，现在已知缺乏经典LTA的革兰氏阳性细菌的数量正在稳步增加，因为人们认识到存在具有与LTA相似的性质和（可能）功能的聚合物。这些聚合物已被不同地称为macroamphiles，脂多糖，或细胞表面糖脂，这是本文的目的，在这一领域的进展进行综述。
Lipoteichoic acids (LTAs) are commonly referred to as membrane-associated polymers characteristic of gram-positive bacteria, just as lipopolysaccharides are believed to be ubiquitous among gram-negative bacteria. Typically a conventional LTA is a linear polymer of 16 to 40 phosphodiester-linked glycerophosphate residues covalently linked to a membrane anchor which is generally analogous to a glycolipid or glycophospholipid found among the free lipids of the cell membrane. The C-2 positions of the glycerophosphate residues may be variably D-alanylated and/or glycosylated. The structures, functions, and biosyntheses of these conventional LTAs have been extensively reviewed (17, 68). However, the number of gram-positive bacteria now known to lack classical LTA is steadily increasing, as is recognition of the occurrence of polymers with properties and (presumably) functions similar to those of LTAs. These polymers have been variously referred to as macroamphiphiles, lipoglycans, or cell surface glycolipids, and it is the purpose of this article to review progress in this field.
金黄色葡萄球菌纤连蛋白受体的分离和表征。
DOI：
--
发表时间：
1987
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Fröman,G;Switalski,LM;Speziale,P;Höök,M
通讯作者：
Höök,M
营养变异型链球菌血清型 I 抗原。
DOI：
--
发表时间：
1988
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
George,M;vandeRijn,I
通讯作者：
vandeRijn,I