Strain-dependent effects of SGS742 in the mouse
Strain-dependent effects of SGS742 in the mouse
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DOI：
10.1016/j.bbr.2007.03.025
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发表时间：
2007-07-19
影响因子：
2.7
通讯作者：
Lubec, Gert
中科院分区：
文献类型：
--
作者：
Sunyer, Berta;Patil, Sudarshan;Lubec, Gert
据报道，SGS 742可以增加啮齿动物的空间记忆。然而，到目前为止，还没有在不同菌株中系统地评估SGS 742的作用，实际上菌株本身显示出不同的认知能力。因此，本研究的目的是检查SGS 742在三种不同的近交系（C57 BL/6 J、DBA/2、BALB/c）品系和三种远交系（CD 1、CF 1、OF 1）中的作用。对小鼠腹膜内给予（3-氨丙基）正丁基次膦酸（SGS 742; GABA（B）-受体拮抗剂），并在Morris水迷宫（MWM）中进行测试。进行了旷场、高架十字迷宫、神经学观察组合和旋转棒以支持数据解释。SGS 742增强了近交系C57 BL/6 J和远交系OF 1在巩固水平的学习和记忆形成方面的MWM表现。注意到一系列副作用，例如运动协调性和本体感受降低，但可能不会影响认知任务中观察到的结果。总之，SGS 742增强了两种小鼠品系的认知能力，我们了解到，测试化合物对空间记忆的影响应该在几种品系甚至不同的物种中进行，以便声称认知增强。(c)2007 Elsevier B. V.保留所有权利。
SGS742 has been reported to increase spatial memory in rodents. However, effects of SGS742 have not been systematically assessed in different strains so far and indeed strains show different cognitive abilities per se. The aim of the study was therefore to examine the effect of SGS742 in three different inbred (C57BL/6J, DBA/2, BALB/c) strains and three outbred strains (CD1, CF1, OF1). Mice were administered intra-peritonial (3-aminopropyl)n-butylphosphinic acid (SGS742; GABA (B)-receptor antagonist) and tested in the Morris water maze (MWM). Open field, elevated plus maze, neurological observational battery and rota rod were carried out to support interpretation of data. SGS742 enhanced performance in the MWM in an inbred strain, C57BL/6J and in the outbred strain OF1 in terms of learning and memory formation at the consolidation level. A series of side effects as e.g. reduced motor coordination and proprioception were noticed that, however, may not have been influencing results observed in the cognition task. In conclusion, SGS742 enhanced cognitive performance in two mouse strains and we learned that testing compounds for effects on spatial memory should be carried out in several strains or even different species in order to claim cognitive enhancement. (c) 2007 Elsevier B.V. All rights reserved.