Mental Health Consequences of Traumatic Brain Injury.
Mental Health Consequences of Traumatic Brain Injury.
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DOI：
10.1016/j.biopsych.2021.09.024
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发表时间：
2022-03-01
影响因子：
10.6
通讯作者：
Stein MB
中科院分区：
文献类型：
--
作者：
Howlett JR;Nelson LD;Stein MB
创伤性脑损伤（TBI）与许多精神和神经行为问题有关。随着严重TBI死亡率的下降，人们的注意力转向了严重程度范围内的认知、情感和行为后遗症，这些后遗症往往比残留的身体影响更能致残。中度和重度TBI可导致性格改变，包括冲动、严重易怒、情感不稳定和冷漠。轻度TBI，曾经被认为是一个很大程度上良性的现象，现在已知与一系列情感症状，自杀倾向，并与恶化或新发的几种精神疾病，包括创伤后应激障碍（PTSD）和重度抑郁症。重复的头部撞击，通常在运动环境中，现在被认为与许多情绪和行为后遗症有关。TBI的精神健康表现的性质和病因（包括脑功能障碍和心理创伤的组合以及认知、情感和身体症状之间的相互关系）是复杂的，并且一直是最近流行病学和机制研究的焦点。本文将回顾流行病学的精神和神经行为问题后，创伤性脑损伤在军事，民用和运动环境。
Traumatic brain injury (TBI) is associated with a host of psychiatric and neurobehavioral problems. As mortality rates have declined for severe TBI, attention has turned to the cognitive, affective, and behavioral sequelae of injuries across the severity spectrum, which are often more disabling than residual physical effects. Moderate and severe TBI can cause personality changes including impulsivity, severe irritability, affective instability, and apathy. Mild TBI, once considered a largely benign phenomenon, is now known to be associated with a range of affective symptoms, with suicidality, and with worsening or new onset of several psychiatric disorders including posttraumatic stress disorder (PTSD) and major depressive disorder. Repetitive head impacts, often in athletic contexts, are now believed to be associated with a number of emotional and behavioral sequelae. The nature and etiology of mental health manifestations of TBI (including a combination of brain dysfunction and psychological trauma and interrelationships between cognitive, affective, and physical symptoms) are complex and have been a focus of recent epidemiologic and mechanistic studies. This paper will review the epidemiology of psychiatric and neurobehavioral problems after TBI in military, civilian, and athletic contexts.
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