The efficiency of sporozoite transmission in the human malarias, Plasmodium falciparum and P. vivax.
The efficiency of sporozoite transmission in the human malarias, Plasmodium falciparum and P. vivax.
复制标题
子孢子在人类疟疾、恶性疟原虫和间日疟原虫中传播的效率。
DOI：
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发表时间：
1987
影响因子：
11.1
通讯作者：
F. Gibson
中科院分区：
文献类型：
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作者：
T. Burkot;P. Graves;J. Cattan;R. Wirtz;F. Gibson
报告了巴布亚新几内亚马当省8个流行病学确定的不同地方性村庄1年期间的疟疾孢子和接种率。在这项研究中，用ELISA分析了41000多只野生蚊子的恶性疟原虫和间日疟原虫孢子虫。在某一村庄，昆虫学接种率与儿童中这两种疟疾寄生虫的流行率密切相关。然而，恶性疟原虫在儿童中的感染率远高于间日疟原虫，尽管这两种疟原虫的接种率相似。这些数据表明，在巴布亚新几内亚，恶性疟原虫比间日疟原虫从蚊子传播到人的效率更高。恶性疟原虫传播效率的提高可能是由于自然感染恶性疟原虫孢子体的野生蚊子的孢子体密度比感染间日疟原虫的蚊子的孢子体密度高10倍。
Reported are malaria sporozoite and inoculation rates over a 1-year period in eight epidemiologically defined villages of different endemicity in Madang Province, Papua New Guinea. In the study, more than 41 000 wild-caught mosquitos were analysed for Plasmodium falciparum and P. vivax sporozoites by ELISA. In a given village the entomological inoculation rates correlated strongly with the prevalences of both these malarial parasites in children. However, the prevalence of P. falciparum infections in children was much higher than that of P. vivax, despite similar inoculation rates for the two species. These data suggest that in Papua New Guinea P. falciparum is more efficiently transmitted than P. vivax from mosquito to man. The increased efficiency of transmission of P. falciparum may be due to the heavier sporozoite densities in wild-caught mosquitos naturally infected with P. falciparum sporozoites that were tenfold greater than the sporozoite densities in mosquitos infected with P. vivax.