Trends in malignant melanoma mortality in 31 countries from 1985 to 2015
Trends in malignant melanoma mortality in 31 countries from 1985 to 2015
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DOI：
10.1111/bjd.19010
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发表时间：
2020-04-13
影响因子：
10.3
通讯作者：
Shalhoub, J.
中科院分区：
文献类型：
--
作者：
Yang, D. D.;Salciccioli, J. D.;Shalhoub, J.
背景恶性黑色素瘤(MM)是皮肤癌中死亡人数最多的疾病。为了评估疾病负担，需要对国际MM死亡率趋势进行最新分析，这可能有助于评估新的诊断、治疗和预防策略的有效性。目的使用世界卫生组织(WHO)死亡率数据库报告1985至2015年间MM死亡率趋势。材料和方法我们使用WHO死亡率数据库中所有具有高可用性死亡登记数据的国家/地区的MM死亡率数据。结果31个国家符合纳入标准。在观察期内，除捷克共和国外，所有国家的男性年龄标化死亡率均有所上升。更多的国家表现出女性多发性骨髓瘤死亡率下降或稳定。2013-2015年死亡率的中位数为男性每10万人中有2人死亡，女性为每10万人中有1人死亡。澳大利亚和挪威的男性ASDR最高(分别为每10万人5个中心点72个和4个中心点55个)。挪威和斯洛文尼亚的女性ASDR最高(分别为3个中心点02/10万和2个中心点58/10万)。在所有国家中，男性的MM死亡率高于女性，性别差距在整个时期不断扩大。在几个国家，老年和年轻人群的死亡率也存在差异。结论在过去30年中，MM死亡率总体上有所上升。然而，不同国家之间、男性和女性之间以及不同年龄段之间的死亡率趋势存在显著差异。关于这个话题，我们已经知道了什么？恶性黑色素瘤(MM)是皮肤癌中死亡率最高的。大多数MM病例可以归因于已知的、可改变的危险因素。据报道，在过去的几十年里，MM的发病率在许多地区有所增加，但最近一些地区的MM发病率和死亡率也出现了稳定和下降的迹象。这项研究增加了什么？研究了过去30年大量不同人群的MM死亡率趋势。观察到MM死亡率的总体上升。除一个国家外，所有国家的男性年龄标化死亡率都有所上升，而更多的国家女性MM死亡率下降或稳定。在所有国家中，MM死亡率男性高于女性，性别差异在整个时期扩大。
Background Malignant melanoma (MM) causes the highest absolute number of deaths among skin cancers. An up-to-date analysis of international MM mortality trends is required for assessing the burden of disease, and may support the assessment of the effectiveness of new diagnostic, therapeutic and preventative strategies.Objectives To report MM mortality trends between 1985 and 2015 using the World Health Organization (WHO) Mortality Database.Materials and methods We used country-level MM mortality data from the WHO Mortality Database for all countries with high usability death registration data. Mortality trends were described using Joinpoint regression modelling.Results Thirty-one countries met the inclusion criteria. All countries, except the Czech Republic, demonstrated increased age-standardized death rates (ASDRs) in males over the observation period. More countries exhibited decreased or stable MM mortality in females. The median mortality rate for 2013-2015 was 2 center dot 57 deaths per 100 000 for males and 1 center dot 55 per 100 000 for females. Australia and Norway had the highest ASDRs for males (5 center dot 72 per 100 000 and 4 center dot 55 per 100 000, respectively). Norway and Slovenia had the highest ASDRs for females (3 center dot 02 per 100 000 and 2 center dot 58 per 100 000, respectively). MM mortality was greater for males than females in all countries, with sex disparity increasing across the period. Disparity in mortality between older and younger cohorts in several countries was also found.Conclusions An overall increase in MM mortality over the past 30 years was observed. However, there was notable variation in mortality trends between countries, as well as between males and females, and between different age groups.What is already known about this topic?Malignant melanoma (MM) has the highest mortality among skin cancers.The majority of MM cases can be attributed to known, modifiable risk factors.The incidence of MM is reported to have increased over past decades in many regions, but recent signs of stabilization and decline in MM incidence and mortality have also been reported in some regions.What does this study add?MM mortality trends across a large number of different populations over the past 30 years were studied.An overall increase in MM mortality was observed.All countries except one demonstrated increased age-standardized death rates in males, while more countries exhibited decreased or stable MM mortality in females.MM mortality was greater in males than in females in all countries, with sex disparity increasing across the period.